| Gene Symbol | ATG7 |
|---|---|
| Entrez Gene | 10533 |
| Alt Symbol | APG7-LIKE, APG7L, GSA7 |
| Species | Human |
| Gene Type | protein-coding |
| Description | autophagy related 7 |
| Other Description | ATG12-activating enzyme E1 ATG7|ATG7 autophagy related 7 homolog|autophagy-related protein 7|hAGP7|ubiquitin activating enzyme E1-like protein|ubiquitin-activating enzyme E1-like protein|ubiquitin-like modifier-activating enzyme ATG7 |
| Swissprots | Q9BWP2 B4E170 Q9UFH4 E9PB95 Q7L8L0 O95352 |
| Accessions | CAF86536 EAW64093 EAW64094 EAW64095 EAW64096 EAW64097 O95352 AF094516 AAC69630 AK075221 BAG52088 AK298833 BAG60963 AK303694 BAG64682 AK314504 BAG37104 AL122075 CAB59250 BC000091 AAH00091 BP373819 DA177126 XM_006712931 XP_006712994 XM_006712932 XP_006712995 XM_006712933 XP_006712996 XM_011533277 XP_011531579 XM_011533278 XP_011531580 XM_011533279 XP_011531581 XM_011533280 XP_011531582 XM_011533281 XP_011531583 XM_011533282 XP_011531584 XM_011533283 XP_011531585 XM_011533284 XP_011531586 XM_011533285 XP_011531587 XM_011533286 XP_011531588 XR_940363 NM_001136031 NP_001129503 NM_001144912 NP_001138384 NM_006395 NP_006386 |
| Function | E1-like activating enzyme involved in the 2 ubiquitin- like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation. {ECO:0000269|PubMed:11096062, ECO:0000269|Pu |
| Subcellular Location | Cytoplasm {ECO:0000250}. Preautophagosomal structure {ECO:0000250}. Note=Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. {ECO:0000250}. |
| Tissue Specificity | Widely expressed, especially in kidney, liver, lymph nodes and bone marrow. {ECO:0000269|PubMed:11890701}. |
| Top Pathways | Regulation of autophagy |