COPS7A

Gene Symbol COPS7A
Entrez Gene 50813
Alt Symbol CSN7, CSN7A, SGN7a
Species Human
Gene Type protein-coding
Description COP9 signalosome subunit 7A
Other Description COP9 complex subunit 7a|COP9 constitutive photomorphogenic homolog subunit 7A|COP9 signalosome complex subunit 7a|JAB1-containing signalosome subunit 7a|dermal papilla-derived protein 10
Swissprots Q9NVX3 A8K9A6 Q9UBW8 Q9UJW4
Accessions CAE90397 CAE91308 EAW88745 EAW88746 EAW88747 EAW88748 EAW88749 Q9UBW8 AB014764 BAB87805 AB033603 BAA85390 AF193844 AAF04307 AF210052 AAF19205 AK001318 BAA91620 AK021721 BAG51042 AK022488 BAB14052 AK128792 BAG54737 AK292621 BAF85310 BC011789 AAH11789 BC093015 AAH93015 BQ008460 DA043679 DA365275 DC355036 DQ892894 ABM83820 DQ896141 ABM87140 HY087807 XM_005253694 XP_005253751 XM_005253695 XP_005253752 NM_001164093 NP_001157565 NM_001164094 NP_001157566 NM_001164095 NP_001157567 NM_016319 NP_057403
Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:9535219}.
Tissue Specificity Widely expressed. Expressed at high level in brain, heart and skeletal muscle. {ECO:0000269|PubMed:12020345}.

CSN7a (H-2) - sc-514067 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CSN7a (H-2): sc-514067. Western blot analysis of CSN7a expression in HeLa (A) and JAR (B) whole cell lysates, SK-N-MC nuclear extract (C) and human lateral ventricle (D) and human heart (E) tissue extracts.

CSN7a (D-6) - sc-398882 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CSN7a (D-6): sc-398882. Western blot analysis of CSN7a expression in SK-N-MC nuclear extract (A), HeLa (B) and JAR (C) whole cell lysates and human lateral ventricle (D) and human heart (E) tissue extracts.

CSN7a (C-14) - sc-47968 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CSN7a (C-14): sc-47968. Immunoperoxidase staining of formalin fixed, paraffin-embedded human placenta tissue showing nuclear and cytoplasmic staining of trophoblastic cells.

CSN7a (H-41) - sc-367016 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CSN7a (H-41): sc-367016. Western blot analysis of CSN7a expression in non-transfected 293T: sc-117752 (A), mouse CSN7a transfected 293T: sc-119484 (B) and U-251-MG (C) whole cell lysates.

CSN7a (N-17) - sc-47971 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CSN7a (N-17): sc-47971. Western blot analysis of CSN7a expression in HeLa (A), Jurkat (B), K-562 (C) and Hep G2 (D) whole cell lysates.

Anti-COPS7A antibody - ab192381 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-COPS7A antibody (ab192381)Lane 1 : Hela cell lysateLane 2 : Raw264.7 cell lysateLane 3 : PC12 cell lysate

Anti-COPS7A antibody - ab167629 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-COPS7A antibody (ab167629) at 1/500 dilutionLane 1 : COPS7A tranfected 293T lysateLane 2 : Non-transfected 293T lysateLysates/proteins at 15 µl per lane.

Anti-COPS7A antibody - ab98898 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-COPS7A antibody (ab98898) at 1 µg/ml + Human fetal heart lysate at 10 µg

Anti-COPS7A antibody [EPR6463] - ab124705 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6463
All lanes : Anti-COPS7A antibody [EPR6463] (ab124705) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : JAR cell lysateLane 3 : Fetal muscle cell lysateLane 4 : Human brain cell lysateLane 5 : Human heart cell lysateLane 6 : Human kidney cell lysateLysates/proteins at 10 µg per lane.

Anti-COPS7A antibody - C-terminal - ab170744 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human pancreas tissue labeling COPS7A  with ab170744 at 1/10 dilution, followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-COPS7A Antibody (aa244-274, APC) - LS-C255261 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPS7A Antibody (aa244-274, AP) - LS-C255260 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPS7A Antibody (aa244-274, Biotin) - LS-C255262 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPS7A Antibody (C-Terminus) - LS-C107924 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
COPS7A antibody LS-C107924 Western blot of Fetal Heart lysate.

Anti-COPS7A Antibody (aa244-274, FITC) - LS-C255263 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPS7A Antibody (Internal, clone EPR6463) - LS-C138805 from LifeSpan Bioscience

Host Rabbit
Clonality Monoclonal
Clone [EPR6463]
Western blot analysis on (A) HeLa, (B) JAR, (C) fetal muscle, (D) human brain, (E) human heart, and (F) human kidney lysates using anti-CSN7A antibody.

Anti-COPS7A Antibody (aa244-274, Azide-free, HRP) - LS-C255264 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPS7A Antibody (aa244-274) - LS-C320524 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPS7A Antibody (aa244-274, PE) - LS-C255265 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPS7A Antibody - LS-C340965 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPS7A Antibody (aa244-274) - LS-C166945 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
COPS7A Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human pancreas tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

COPS7A Antibody - NBP1-53118 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: COPS7A Antibody [NBP1-53118] - Sample Type: 1. Markers 2. B8 mouse fibroblast cells, extraction only 3. Human total cells, pure Primary Dilution: 1:500 Secondary Anitbody: HRP conjugated anti-rabbit Image Submitted By: Dr. Elah Pick University of Haifa at Oranim

COPS7A Antibody - NBP1-84369 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: COPS7A Antibody [NBP1-84369] - Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.

COPS7A Antibody - H00050813-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: COPS7A Antibody [H00050813-B01] - analysis of COPS7A expression in transfected 293T cell line by COPS7A MaxPab polyclonal antibody (B01). Lane 1: COPS7A transfected lysate (30.30 KDa). Lane 2: Non-transfected lysate.

COPS7A Polyclonal Antibody - bs-9124R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Search more