COPS7A

Gene Symbol COPS7A
Entrez Gene 50813
Alt Symbol CSN7, CSN7A, SGN7a
Species Human
Gene Type protein-coding
Description COP9 signalosome subunit 7A
Other Description COP9 complex subunit 7a|COP9 constitutive photomorphogenic homolog subunit 7A|COP9 signalosome complex subunit 7a|JAB1-containing signalosome subunit 7a|dermal papilla-derived protein 10
Swissprots Q9NVX3 A8K9A6 Q9UBW8 Q9UJW4
Accessions CAE90397 CAE91308 EAW88745 EAW88746 EAW88747 EAW88748 EAW88749 Q9UBW8 AB014764 BAB87805 AB033603 BAA85390 AF193844 AAF04307 AF210052 AAF19205 AK001318 BAA91620 AK021721 BAG51042 AK022488 BAB14052 AK128792 BAG54737 AK292621 BAF85310 BC011789 AAH11789 BC093015 AAH93015 BQ008460 DA043679 DA365275 DC355036 DQ892894 ABM83820 DQ896141 ABM87140 HY087807 XM_005253694 XP_005253751 XM_005253695 XP_005253752 NM_001164093 NP_001157565 NM_001164094 NP_001157566 NM_001164095 NP_001157567 NM_016319 NP_057403
Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:9535219}.
Tissue Specificity Widely expressed. Expressed at high level in brain, heart and skeletal muscle. {ECO:0000269|PubMed:12020345}.

CSN7a CRISPR/Cas9 KO Plasmid (h) - sc-408503 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN7a HDR Plasmid (h) - sc-408503-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN7a Double Nickase Plasmid (h) - sc-408503-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN7a Double Nickase Plasmid (h2) - sc-408503-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN7a CRISPR Activation Plasmid (h) - sc-408503-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN7a CRISPR Activation Plasmid (h2) - sc-408503-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN7a Lentiviral Activation Particles (h) - sc-408503-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN7a Lentiviral Activation Particles (h2) - sc-408503-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN7a siRNA (h) - sc-60463 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CSN7a shRNA Plasmid (h) - sc-60463-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CSN7a shRNA (h) Lentiviral Particles - sc-60463-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU019911 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6437 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6437 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06790 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr06790

COPS7A siRNA (Human) - CRH9410 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

COPS7A - MBS8233695 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human COPS7A (NM_016319.2) - SHH267853 from Creative biogene

Category siRNA
Species Reactivities Human

Human COPS7A siRNA - orb269912 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

COPS7A shRNA Plasmid (Human) - CHH9410 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

COPS7A miRNA 3'UTR clone - MiUTR3H-14501 from Creative biogene

Species Reactivities Human

COPS7A miRNA 3'UTR clone - MiUTR3H-14502 from Creative biogene

Species Reactivities Human

COPS7A miRNA 3'UTR clone - MiUTR3H-14503 from Creative biogene

Species Reactivities Human

COPS7A miRNA 3'UTR clone - MiUTR3H-14504 from Creative biogene

Species Reactivities Human
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