| Gene Symbol |
COPS7A
|
| Entrez Gene |
50813
|
| Alt Symbol |
CSN7, CSN7A, SGN7a
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
COP9 signalosome subunit 7A
|
| Other Description |
COP9 complex subunit 7a|COP9 constitutive photomorphogenic homolog subunit 7A|COP9 signalosome complex subunit 7a|JAB1-containing signalosome subunit 7a|dermal papilla-derived protein 10
|
| Swissprots |
Q9NVX3 A8K9A6 Q9UBW8 Q9UJW4
|
| Accessions |
CAE90397 CAE91308 EAW88745 EAW88746 EAW88747 EAW88748 EAW88749 Q9UBW8 AB014764 BAB87805 AB033603 BAA85390 AF193844 AAF04307 AF210052 AAF19205 AK001318 BAA91620 AK021721 BAG51042 AK022488 BAB14052 AK128792 BAG54737 AK292621 BAF85310 BC011789 AAH11789 BC093015 AAH93015 BQ008460 DA043679 DA365275 DC355036 DQ892894 ABM83820 DQ896141 ABM87140 HY087807 XM_005253694 XP_005253751 XM_005253695 XP_005253752 NM_001164093 NP_001157565 NM_001164094 NP_001157566 NM_001164095 NP_001157567 NM_016319 NP_057403
|
| Function |
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:9535219}.
|
| Tissue Specificity |
Widely expressed. Expressed at high level in brain, heart and skeletal muscle. {ECO:0000269|PubMed:12020345}.
|