COPS7A

Gene Symbol	COPS7A
Entrez Gene	50813
Alt Symbol	CSN7, CSN7A, SGN7a
Species	Human
Gene Type	protein-coding
Description	COP9 signalosome subunit 7A
Other Description	COP9 complex subunit 7a|COP9 constitutive photomorphogenic homolog subunit 7A|COP9 signalosome complex subunit 7a|JAB1-containing signalosome subunit 7a|dermal papilla-derived protein 10
Swissprots	Q9NVX3 A8K9A6 Q9UBW8 Q9UJW4
Accessions	CAE90397 CAE91308 EAW88745 EAW88746 EAW88747 EAW88748 EAW88749 Q9UBW8 AB014764 BAB87805 AB033603 BAA85390 AF193844 AAF04307 AF210052 AAF19205 AK001318 BAA91620 AK021721 BAG51042 AK022488 BAB14052 AK128792 BAG54737 AK292621 BAF85310 BC011789 AAH11789 BC093015 AAH93015 BQ008460 DA043679 DA365275 DC355036 DQ892894 ABM83820 DQ896141 ABM87140 HY087807 XM_005253694 XP_005253751 XM_005253695 XP_005253752 NM_001164093 NP_001157565 NM_001164094 NP_001157566 NM_001164095 NP_001157567 NM_016319 NP_057403
Function	Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:9535219}.
Tissue Specificity	Widely expressed. Expressed at high level in brain, heart and skeletal muscle. {ECO:0000269|PubMed:12020345}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human COPS7A full length protein - ab162359 from Abcam Category Protein Source Wheat germ Species Human

Human COPS7A full length protein - ab180281 from Abcam Category Protein Source E. coli Species Human

COPS7A Antibody Blocking Peptide - LS-E1957 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

COPS7A Antibody Blocking Peptide - LS-E20725 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

COPS7A Recombinant Protein - H00050813-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

COPS7A-Antibody-C-term-Blocking-peptide - BP12810b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human COPS7A protein - orb244971 from Biorbyt Category Protein Prices $213.00, $408.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Human

COPS7A Blocking Peptide - 33R-6762 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

COPS7A protein (His tag) - 80R-3785 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

COPS7A Blocking Peptide - abx063849 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

COPS7A (1-275, His-tag) - AR51472PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

COPS7A (1-275, His-tag) - AR51472PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

COPS7A - H00050813-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

COPS7A, 1-275aa, Human, His tag, E.coli - 01-P2652 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

COPS7A fusion protein - Ag9958 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

COPS7A fusion protein - Ag9167 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human COPS7A, GST-tagged - COPS7A-11463H from Creative Biomart Category Protein Source E.coli Species Human

COPS7A Blocking Peptide - CBP2655 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey

Recombinant Human COP9 signalosome complex subunit 7a(COPS7A) - CSB-YP880068HU CSB-BP880068HU CSB-MP880068HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant human COP9 signalosome complex subunit 7a - CSB-EP880068HU from Cusabio Category Protein Source E.coli Species Human

COPS7A, 1-275aa, Human, His tag, E.coli (Denatured) - ATGP2652 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 20 µg, 100 µg, 500 µg Species Human

COPS7A Protein - abx164522 from Abbexa Category Protein Species Human, Mouse, Rat

COPS7A - TP303965 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Human COPS7A protein - orb259854 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

COPS7A Protein - NBP1-84369PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

Search more