ERBB4

Gene Symbol	ERBB4
Entrez Gene	2066
Alt Symbol	ALS19, HER4, p180erbB4
Species	Human
Gene Type	protein-coding
Description	erb-b2 receptor tyrosine kinase 4
Other Description	avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4|human epidermal growth factor receptor 4|proto-oncogene-like protein c-ErbB-4|receptor tyrosine-protein kinase erbB-4|tyrosine kinase-type cell surface receptor HER4|v-erb-a erythroblastic leukemia viral oncogene homolog 4|v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
Swissprots	Q59EW4 B7ZLD7 Q2M1W1 B7ZLE3 Q15303 B7ZLE2
Accessions	AAX82011 AAX88856 AAY14899 AAY15092 AAY24158 AAY24303 CAJ55818 CCQ43309 EAW70496 EAW70497 EAW70498 Q15303 AB209697 BAD92934 AF007153 AI793060 AK024204 AK126298 AK308606 BC112199 AAI12200 BC143741 AAI43742 BC143747 AAI43748 BC143749 AAI43750 BQ015804 CR627023 L07868 AAB59446 XM_005246375 XP_005246432 XM_005246376 XP_005246433 XM_005246377 XP_005246434 XM_006712364 XP_006712427 NM_001042599 NP_001036064 NM_005235 NP_005226
Function	Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alter
Subcellular Location	Cell membrane {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19193720, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:9334263}; Single-pass type I membrane protein {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19193720, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:9334263}. Note=In response to NRG1 treatment, the activated receptor is internalized.
Tissue Specificity	Expressed at highest levels in brain, heart, kidney, in addition to skeletal muscle, parathyroid, cerebellum, pituitary, spleen, testis and breast. Lower levels in thymus, lung, salivary gland, and pancreas. Isoform JM-A CYT-1 and isoform JM-B CYT-1 are expressed in cerebellum, but only the isoform JM-B is expressed in the heart. {ECO:0000269|PubMed:10353604, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:9334263}.
Top Pathways	ErbB signaling pathway, Calcium signaling pathway, Endocytosis, Proteoglycans in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PathScan ® Phospho-HER4/ErbB4 (panTyr) Sandwich ELISA Kit - 13125 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

PathScan ® Total HER4/ErbB4 Sandwich ELISA Kit - 13010 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

HTScan® HER4/ErbB4 Kinase Assay Kit - 7725 from Cell Signaling Technology Category Assay Kit

Human ERBB4 / HER4 ELISA Kit (Sandwich ELISA) - LS-F9465 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.062 ng/ml Range 0.156-10 ng/ml

Rabbit anti-ErbB4 Antibody, Affinity Purified - PLA0129 from Sigma-Aldrich

Phosphotyrosine ERBB4 / Receptor Tyrosine-protein Kinase erbB-4 ELISA Kit - RAB0957 from Sigma-Aldrich Category ELISA Kit Prices $637.00 Sizes 1 kt

Human Phospho-ErbB4/Her4 (Y1188) Cell-Based ELISA - KCB4418 from R&D Systems Category ELISA Kit Prices $459.00 Sizes 1 kit

Human Phospho-ErbB4/Her4 DuoSet IC ELISA - DYC2115-2 from R&D Systems Category ELISA Kit Prices $329.00, $649.00 Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates)

Human Phospho-ErbB4/Her4 DuoSet IC, 5 Plate - DYC2115-5 from R&D Systems Category ELISA Kit

Human Total ErbB4/Her4 DuoSet IC ELISA - DYC1133-2 from R&D Systems Category ELISA Kit Prices $329.00, $649.00 Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates) Range 125.00 - 8,000 pg/mL

Human Total ErbB4/Her4 DuoSet IC, 5 Plate - DYC1133-5 from R&D Systems Category ELISA Kit

Human ErbB4 ELISA Kit - abx151442 from Abbexa Category ELISA Kit Sensitivity 0.062 ng/ml Range 0.156 ng/ml - 10 ng/ml

Receptor tyrosine-protein kinase erbB-4 (ERBB4), Human, ELISA Kit - CSB-EL007766HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

V-Erb A Erythroblastic Leukemia Viral Oncogene Homolog 4 (ErbB4), Human, ELISA Kit - SEC188Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.062ng/mL Range 0.156-10ng/mL.

Custom Human ErbB4 ELISA - ELH-ErbB4 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Anserine PGI2 ELISA Kit - AP0034 from NeoScientific Category ELISA Kit Prices $300.00, $480.00 Sizes 100 µl, 200 µl

receptor tyrosine kinase, RTKs - MBS9302585 from MyBioSource Category ELISA Kit Prices $435.00, $600.00 Sizes 48 strip wells, 96 strip wells

v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) , ELISA Kit - MBS915273 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for V-Erb A Erythroblastic Leukemia Viral Oncogene Homolog 4 (ErbB4) - SEC188Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.062ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human Receptor tyrosine-protein kinase erbB-4(ERBB4) ELISA kit - CSB-EL007766HU from Cusabio Category ELISA Kit Sensitivity Request Information Range Request Information

ELISA Kit for V-Erb A Erythroblastic Leukemia Viral Oncogene Homolog 4 (ErbB4) - SEC188Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.062ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human Phospho-ErbB4/Her4 (Y1188) ELISA Kit - DEIA-XY2259 from Creative Diagnostics Category ELISA Kit

Human ErbB4 ELISA kit - orb196670 from Biorbyt Category ELISA Kit Prices $765.00, $1,292.00, $2,754.00 Sizes 96 assays, 192 assays, 480 assays

Human ErbB4 ELISA Kit - abx571829 from Abbexa Category ELISA Kit Sensitivity 0.062 ng/ml Range 0.156 ng/ml - 10 ng/ml

Human ErbB4 ELISA Kit - RAB1041 from Sigma-Aldrich Category ELISA Kit Prices $390.00 Sizes 1 kt Sensitivity 0.2 ng/ml

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