ERBB4
| Gene Symbol | ERBB4 |
|---|---|
| Entrez Gene | 2066 |
| Alt Symbol | ALS19, HER4, p180erbB4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | erb-b2 receptor tyrosine kinase 4 |
| Other Description | avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4|human epidermal growth factor receptor 4|proto-oncogene-like protein c-ErbB-4|receptor tyrosine-protein kinase erbB-4|tyrosine kinase-type cell surface receptor HER4|v-erb-a erythroblastic leukemia viral oncogene homolog 4|v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 |
| Swissprots | Q59EW4 B7ZLD7 Q2M1W1 B7ZLE3 Q15303 B7ZLE2 |
| Accessions | AAX82011 AAX88856 AAY14899 AAY15092 AAY24158 AAY24303 CAJ55818 CCQ43309 EAW70496 EAW70497 EAW70498 Q15303 AB209697 BAD92934 AF007153 AI793060 AK024204 AK126298 AK308606 BC112199 AAI12200 BC143741 AAI43742 BC143747 AAI43748 BC143749 AAI43750 BQ015804 CR627023 L07868 AAB59446 XM_005246375 XP_005246432 XM_005246376 XP_005246433 XM_005246377 XP_005246434 XM_006712364 XP_006712427 NM_001042599 NP_001036064 NM_005235 NP_005226 |
| Function | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alter |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19193720, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:9334263}; Single-pass type I membrane protein {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19193720, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:9334263}. Note=In response to NRG1 treatment, the activated receptor is internalized. |
| Tissue Specificity | Expressed at highest levels in brain, heart, kidney, in addition to skeletal muscle, parathyroid, cerebellum, pituitary, spleen, testis and breast. Lower levels in thymus, lung, salivary gland, and pancreas. Isoform JM-A CYT-1 and isoform JM-B CYT-1 are expressed in cerebellum, but only the isoform JM-B is expressed in the heart. {ECO:0000269|PubMed:10353604, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:9334263}. |
| Top Pathways | ErbB signaling pathway, Calcium signaling pathway, Endocytosis, Proteoglycans in cancer |
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