ERBB4

Gene Symbol	ERBB4
Entrez Gene	2066
Alt Symbol	ALS19, HER4, p180erbB4
Species	Human
Gene Type	protein-coding
Description	erb-b2 receptor tyrosine kinase 4
Other Description	avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4|human epidermal growth factor receptor 4|proto-oncogene-like protein c-ErbB-4|receptor tyrosine-protein kinase erbB-4|tyrosine kinase-type cell surface receptor HER4|v-erb-a erythroblastic leukemia viral oncogene homolog 4|v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
Swissprots	Q59EW4 B7ZLD7 Q2M1W1 B7ZLE3 Q15303 B7ZLE2
Accessions	AAX82011 AAX88856 AAY14899 AAY15092 AAY24158 AAY24303 CAJ55818 CCQ43309 EAW70496 EAW70497 EAW70498 Q15303 AB209697 BAD92934 AF007153 AI793060 AK024204 AK126298 AK308606 BC112199 AAI12200 BC143741 AAI43742 BC143747 AAI43748 BC143749 AAI43750 BQ015804 CR627023 L07868 AAB59446 XM_005246375 XP_005246432 XM_005246376 XP_005246433 XM_005246377 XP_005246434 XM_006712364 XP_006712427 NM_001042599 NP_001036064 NM_005235 NP_005226
Function	Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alter
Subcellular Location	Cell membrane {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19193720, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:9334263}; Single-pass type I membrane protein {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19193720, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:9334263}. Note=In response to NRG1 treatment, the activated receptor is internalized.
Tissue Specificity	Expressed at highest levels in brain, heart, kidney, in addition to skeletal muscle, parathyroid, cerebellum, pituitary, spleen, testis and breast. Lower levels in thymus, lung, salivary gland, and pancreas. Isoform JM-A CYT-1 and isoform JM-B CYT-1 are expressed in cerebellum, but only the isoform JM-B is expressed in the heart. {ECO:0000269|PubMed:10353604, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:9334263}.
Top Pathways	ErbB signaling pathway, Calcium signaling pathway, Endocytosis, Proteoglycans in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human ErbB 4 protein fragment - ab85602 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Insect cells Species Human

Active human ErbB 4 protein fragment - ab155610 from Abcam Category Protein Prices $352.00 Sizes 100 µg Source HEK 293 cells Species Human

Active human ErbB 4 protein fragment - ab176949 from Abcam Category Protein Prices $298.00 Sizes 5 µg Source HEK 293 cells Species Human

Human ErbB 4 protein fragment - ab152368 from Abcam Category Protein Source Wheat germ Species Human

Human ErbB 4 protein fragment - ab61640 from Abcam Category Protein Source Insect cells Species Human

ERBB4 / HER4 Antibody Blocking Peptide - LS-E6029 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ERBB4 / HER4 Antibody Blocking Peptide - LS-E28753 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ERBB4 / HER4 Antibody Blocking Peptide - LS-E28754 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ERBB4 / HER4 Antibody Blocking Peptide - LS-E7277 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ERBB4 / HER4 Antibody Blocking Peptide - LS-E7278 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ERBB4 / HER4 Antibody Blocking Peptide - LS-E28639 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ERBB4 / HER4 Antibody Blocking Peptide - LS-E28640 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ERBB4 / HER4 Antibody Blocking Peptide - LS-E9128 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ERBB4 / HER4 Antibody Blocking Peptide - LS-E9127 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ErbB4/Her4 Protein - H00002066-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ErbB4/Her4 Peptide - P1332 from Novus Biologicals Category Peptide Species Human

ErbB4/Her4 Peptide - P1331 from Novus Biologicals Category Peptide Species Human

ErbB4/Her4 Peptide - P2656 from Novus Biologicals Category Peptide Species Human

ErbB4/Her4 Peptide - P2655 from Novus Biologicals Category Peptide Species Human

HER4-Antibody-C-term-Y1162-Blocking-Peptide - BP18606b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Phospho-HER4Y1188-Antibody-Blocking-peptide - BP3124a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Phospho-HER4Y1162-Antibody-Blocking-peptide - BP3122a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

ERBB4-AntibodyC-term-Blocking-peptide - BP7631b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ERBB4-AntibodyN-term-Blocking-peptide - BP7631a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human ErbB4 Fc Chimera, CF - 1131-ER-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

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