ERBB4

Gene Symbol ERBB4
Entrez Gene 2066
Alt Symbol ALS19, HER4, p180erbB4
Species Human
Gene Type protein-coding
Description erb-b2 receptor tyrosine kinase 4
Other Description avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4|human epidermal growth factor receptor 4|proto-oncogene-like protein c-ErbB-4|receptor tyrosine-protein kinase erbB-4|tyrosine kinase-type cell surface receptor HER4|v-erb-a erythroblastic leukemia viral oncogene homolog 4|v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
Swissprots Q59EW4 B7ZLD7 Q2M1W1 B7ZLE3 Q15303 B7ZLE2
Accessions AAX82011 AAX88856 AAY14899 AAY15092 AAY24158 AAY24303 CAJ55818 CCQ43309 EAW70496 EAW70497 EAW70498 Q15303 AB209697 BAD92934 AF007153 AI793060 AK024204 AK126298 AK308606 BC112199 AAI12200 BC143741 AAI43742 BC143747 AAI43748 BC143749 AAI43750 BQ015804 CR627023 L07868 AAB59446 XM_005246375 XP_005246432 XM_005246376 XP_005246433 XM_005246377 XP_005246434 XM_006712364 XP_006712427 NM_001042599 NP_001036064 NM_005235 NP_005226
Function Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alter
Subcellular Location Cell membrane {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19193720, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:9334263}; Single-pass type I membrane protein {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19193720, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:9334263}. Note=In response to NRG1 treatment, the activated receptor is internalized.
Tissue Specificity Expressed at highest levels in brain, heart, kidney, in addition to skeletal muscle, parathyroid, cerebellum, pituitary, spleen, testis and breast. Lower levels in thymus, lung, salivary gland, and pancreas. Isoform JM-A CYT-1 and isoform JM-B CYT-1 are expressed in cerebellum, but only the isoform JM-B is expressed in the heart. {ECO:0000269|PubMed:10353604, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:9334263}.
Top Pathways ErbB signaling pathway, Calcium signaling pathway, Endocytosis, Proteoglycans in cancer

Phospho-HER4/ErbB4 (Tyr984) Antibody - 3790 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from T-47D cells, untreated or heregulin-stimulated, using Phospho-HER4/ErbB4 (Tyr984) Antibody (upper) and HER4/ErbB4 (111B2) Rabbit mAb

Phospho-HER4/ErbB4 (Tyr1284) (21A9) Rabbit mAb - 4757 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 21A9
Western blot analysis of extracts from various cell lines expressing different activated protein tyrosine kinases, using Phospho-HER4/ErbB4 (Tyr1284) (21A9) Rabbit mAb or Phospho-Tyrosine Mouse mAb (P-Tyr-100) #9411 (lower).

HER4/ErbB4 (111B2) Rabbit mAb - 4795 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 111B2
Western blot analysis of extracts from various cell lines, using HER4/ErbB4 (111B2) Rabbit mAb .

HER4/ErbB4 (83B10) Rabbit mAb (IHC Specific) - 4792 from Cell Signaling Technology

Host Rabbit
Clonality Monoclonal
Clone 83B10

ErbB-4 (C-7) - sc-8050 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ErbB-4 (C-7): sc-8050. Immunofluorescence staining of methanol-fixed NIH/3T3 cells transfected with ErbB-4 showing membrane localization.

ErbB-4 (A-5) - sc-514327 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ErbB-4 (A-5): sc-514327. Western blot analysis of ErbB-4 expression in non-transfected (A) and human ErbB-4 transfected (B) NIH/3T3 whole cell lysates.

ErbB-4 (G-6) - sc-514462 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ErbB-4 (A-5): sc-514462. Western blot analysis of ErbB-4 expression in non-transfected (A) and human ErbB-4 transfected (B) NIH/3T3 whole cell lysates.

ErbB-4 (C-18) - sc-283 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ErbB-4 (C-18)-G: sc-283-G. Western blot analysis of non-transfected (A) and ErbB-4-transfected (B) NIH/3T3 cells.

ErbB-4 (T-18) - sc-31151 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ErbB-4 (T-18): sc-31151. Western blot analysis of ErbB-4 expression in ErbB-4-transfected NIH/3T3 whole cell lysate.

ErbB-4 (L-20) - sc-31149 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ErbB-4 (L-20): sc-31149. Immunoperoxidase staining of formalin fixed, paraffin-embedded human placenta tissue showing cytoplasmic and nuclear staining of trophoblastic cells and decidual cells.

ErbB-4 (HFR1) - sc-53280 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ErbB-4 (HFR1): sc-53280. Western blot analysis of ErbB-4 expression in ErbB-4 transfected NIH/3T3 whole cell lysate.

ErbB-4 (G-20) - sc-31150 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ErbB-4 (G-20): sc-31150. Western blot analysis of ErbB-4 expression in mouse brain tissue extract.

ErbB-4 (2Q322) - sc-71071 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ErbB-4 (2Q322): sc-71071. Western blot analysis of ErbB-4 expression in T47-14 whole cell lysate.

ErbB-4 (6C5) - sc-81456 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
ErbB-4 (6C5): sc-81456. Western blot analysis of ErbB-4 expression in serum starved MDA-MB-231 (A), MDA-MB-468 (B), MCF7 (C), T-47D (D), SW480 (E) and SW620 (F) whole cell lysates.

ErbB-4 (3F168) - sc-71070 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ErbB-4 (3F168): sc-71070. Western blot analysis of ErbB-4 expression in T47-14 whole cell lysate.

p-ErbB-4 (Tyr 1056) - sc-33040 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
p-ErbB-4 (Tyr 1056): sc-33040. Western blot analysis of ErbB-4 phosphorylation in untreated (A) and EGF-treated (B) A-431 whole cell lysates.

p-ErbB-4 (4C6) - sc-81491 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
p-ErbB-4 (4C6): sc-81491. Western blot analysis of ErbB-4 phosphorylation in untreated (A), EGF treated (B) and EGF treated and lambda protein phosphatase treated (C) A-431 whole cell lysates.

Anti-ErbB 4 (phospho Y1056) antibody [EPR2269] - ab92782 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2269
All lanes : Anti-ErbB 4 (phospho Y1056) antibody [EPR2269] (ab92782) at 1/1000 dilutionLane 1 : A431 cell lysate (Untreated)Lane 2 : A431 cell lysate (Treated with Pervanadate)Lysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-ErbB 4 (phospho Y1162) antibody [EP2270Y] - ab68478 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP2270Y
All lanes : Anti-ErbB 4 (phospho Y1162) antibody [EP2270Y] (ab68478) at 1/500 dilutionLane 1 : A431 cell lysate. Cells untreated.Lane 2 : A431 cell lysate. Cells treated with EGF.Lysates/proteins at 10 µg per lane.SecondaryHRP conjugated Goat anti-Rabbit at 1/2000 dilution

Anti-ErbB 4 (phospho Y1188) antibody [EPR2271Y] - ab68479 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2271Y
All lanes : Anti-ErbB 4 (phospho Y1188) antibody [EPR2271Y] (ab68479) at 1/2000 dilutionLane 1 : A431 cell lysate. Cells untreated.Lane 2 : A431 cell lysate. Cells treated with EGF.Lysates/proteins at 10 µg per lane.SecondaryHRP conjugated Goat anti-Rabbit at 1/2000 dilution

Anti-ErbB 4 (phospho Y1258) antibody [EP2272AY] - ab76132 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP2272AY
All lanes : Anti-ErbB 4 (phospho Y1258) antibody [EP2272AY] (ab76132) at 1/2000 dilutionLane 1 : SKBR3 cell lysates treated with EGFLane 2 : SKBR3 cell lysates untreatedLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-ErbB 4 (phospho Y1284) antibody - ab61059 from Abcam

Prices $380.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab61059 staining ErbB 4 (phospho Y1284) in rat heart tissue sections by ICC/IF (Immunocytochemistry/immunofluorescence). Sections were fixed with paraformaldehyde, permeabilized with 0.05% Tween20 and blocked with 5% BSA + normal goat serum for 4 hours at 21°C. Samples were incubated with primary antibody (1/30 in 5% BSA + 0.05% Tween20 in TBS) for 12 hours at 4°C. ab150077, a goat anti-rabbit  Alexa 488 (1/200) was used as the secondary antibody.See Abreview

Anti-ErbB 4 (phospho Y1284) antibody - ab182634 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ErbB 4 (phospho Y1284) antibody (ab182634) at 1/500 dilutionLane 1 : HUVEC cells treated with EGF with immunizing peptideLane 2 : HUVEC cells treated with EGF

Anti-ErbB 4 (phospho Y1284) antibody - ab195951 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ErbB 4 (phospho Y1284) antibody (ab195951) at 1/500 dilutionLane 1 : EGF-treated HUVEC whole cell lysate with antigen-specific peptideLane 2 : EGF-treated HUVEC whole cell lysateLysates/proteins at 12.5 µg per lane.

Anti-ErbB 4 (phospho Y1284) antibody [EPR2273(2)] - ab109273 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2273(2)
All lanes : Anti-ErbB 4 (phospho Y1284) antibody [EPR2273(2)] (ab109273) at 1/1000 dilutionLane 1 : A431 cell lysate, untreatedLane 2 : A431 cell lysate, treated with Epidermal Growth Factor (EGF) Lysates/proteins at 10 µg/ml per lane.
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