| Gene Symbol |
CARM1
|
| Entrez Gene |
10498
|
| Alt Symbol |
PRMT4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
coactivator-associated arginine methyltransferase 1
|
| Other Description |
histone-arginine methyltransferase CARM1|protein arginine N-methyltransferase 4
|
| Swissprots |
Q86X55 A6NN38
|
| Accessions |
EAW84155 EAW84156 Q86X55 AF055027 AL833242 BC036886 BC046240 AAH46240 BC070496 BC156435 AAI56436 BC172490 AAI72490 BU176535 XM_005259708 XP_005259765 XM_011527637 XP_011525939 XM_011527638 XP_011525940 NM_199141 NP_954592
|
| Function |
Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differenti
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Mainly nuclear during the G1, S and G2 phases of the cell cycle. Cytoplasmic during mitosis, after breakup of the nuclear membrane.
|
| Tissue Specificity |
Overexpressed in prostate adenocarcinomas and high-grade prostatic intraepithelial neoplasia. {ECO:0000269|PubMed:15221992}.
|