CARM1
| Gene Symbol | CARM1 |
|---|---|
| Entrez Gene | 10498 |
| Alt Symbol | PRMT4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | coactivator-associated arginine methyltransferase 1 |
| Other Description | histone-arginine methyltransferase CARM1|protein arginine N-methyltransferase 4 |
| Swissprots | Q86X55 A6NN38 |
| Accessions | EAW84155 EAW84156 Q86X55 AF055027 AL833242 BC036886 BC046240 AAH46240 BC070496 BC156435 AAI56436 BC172490 AAI72490 BU176535 XM_005259708 XP_005259765 XM_011527637 XP_011525939 XM_011527638 XP_011525940 NM_199141 NP_954592 |
| Function | Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differenti |
| Subcellular Location | Nucleus. Cytoplasm. Note=Mainly nuclear during the G1, S and G2 phases of the cell cycle. Cytoplasmic during mitosis, after breakup of the nuclear membrane. |
| Tissue Specificity | Overexpressed in prostate adenocarcinomas and high-grade prostatic intraepithelial neoplasia. {ECO:0000269|PubMed:15221992}. |
CARM1 CRISPR/Cas9 KO Plasmid (h) - sc-404087 from Santa Cruz Biotechnology
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CARM1 HDR Plasmid (h) - sc-404087-HDR from Santa Cruz Biotechnology
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CARM1 Double Nickase Plasmid (h) - sc-404087-NIC from Santa Cruz Biotechnology
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CARM1 Double Nickase Plasmid (h2) - sc-404087-NIC-2 from Santa Cruz Biotechnology
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CARM1 CRISPR Activation Plasmid (h) - sc-404087-ACT from Santa Cruz Biotechnology
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CARM1 CRISPR Activation Plasmid (h2) - sc-404087-ACT-2 from Santa Cruz Biotechnology
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CARM1 Lentiviral Activation Particles (h) - sc-404087-LAC from Santa Cruz Biotechnology
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CARM1 Lentiviral Activation Particles (h2) - sc-404087-LAC-2 from Santa Cruz Biotechnology
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CARM1 siRNA (h) - sc-44875 from Santa Cruz Biotechnology
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CARM1 shRNA Plasmid (h) - sc-44875-SH from Santa Cruz Biotechnology
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CARM1 shRNA (h) Lentiviral Particles - sc-44875-V from Santa Cruz Biotechnology
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Carm1 RNAi - H00010498-R01 from Novus Biologicals
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MISSION® esiRNA - EHU066371 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1581 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1581 from Sigma-Aldrich
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CARM1 siRNA (Human) - CRH7134 from Cohesion Biosciences
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CARM1 - MBS8230728 from MyBioSource
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CARM1 CRISPR/Cas9 KO Plasmid (h2) - sc-404087-KO-2 from Santa Cruz Biotechnology
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CARM1 HDR Plasmid (h2) - sc-404087-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human Carm1 (NM_199141.1) - SHH254773 from Creative biogene
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Human CARM1 siRNA - orb267636 from Biorbyt
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CARM1 shRNA Plasmid (Human) - CHH7134 from Cohesion Biosciences
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CARM1 miRNA 3'UTR clone - MiUTR1H-01673 from Creative biogene
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