CARM1

Gene Symbol	CARM1
Entrez Gene	10498
Alt Symbol	PRMT4
Species	Human
Gene Type	protein-coding
Description	coactivator-associated arginine methyltransferase 1
Other Description	histone-arginine methyltransferase CARM1|protein arginine N-methyltransferase 4
Swissprots	Q86X55 A6NN38
Accessions	EAW84155 EAW84156 Q86X55 AF055027 AL833242 BC036886 BC046240 AAH46240 BC070496 BC156435 AAI56436 BC172490 AAI72490 BU176535 XM_005259708 XP_005259765 XM_011527637 XP_011525939 XM_011527638 XP_011525940 NM_199141 NP_954592
Function	Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differenti
Subcellular Location	Nucleus. Cytoplasm. Note=Mainly nuclear during the G1, S and G2 phases of the cell cycle. Cytoplasmic during mitosis, after breakup of the nuclear membrane.
Tissue Specificity	Overexpressed in prostate adenocarcinomas and high-grade prostatic intraepithelial neoplasia. {ECO:0000269|PubMed:15221992}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PRMT4 peptide - ab2422 from Abcam Category Peptide

Human PRMT4 protein fragment - ab161025 from Abcam Category Protein Source Wheat germ Species Human

PRMT4 / CARM1 Antibody Blocking Peptide - LS-E912 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRMT4 / CARM1 Antibody Blocking Peptide - LS-E4620 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRMT4 / CARM1 Antibody Blocking Peptide - LS-E31393 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human Carm1 Protein - H00010498-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Carm1 Peptide - P0146 from Novus Biologicals Category Peptide Species Human

PRMT4-AntibodyCenter-Blocking-peptide - BP11313c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CARM1-Antibody-Center-Blocking-Peptide - BP16980c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CARM1 Blocking Peptide - 33R-10908 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

CARM1 / PRMT4 - H00010498-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CARM1 / PRMT4 - H00010498-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CARM1 Peptide - 7219P from ProSci Category Peptide Species Human

Recombinant Human CARM1 - CARM1-451H from Creative Biomart Category Protein Source FreeStyle 293-F cells .

Recombinant Human CARM1, His-tagged - CARM1-617H from Creative Biomart Category Protein Source Sf21 Cells.

Recombinant Human CARM1, Flag-tagged - CARM1-999H from Creative Biomart Category Protein Source sf9 Cells Species Human

Recombinant Human CARM1 - CARM1-670H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Human recombinant CARM1 - 14-1048 from EMD Millipore Prices $380.00 Sizes 10 µg Source Human Species Human

CARM1, active protein, N-terminal His-tagged - 14-575 from EMD Millipore Category Protein Source Recombinant mouse CARM expressed in Sf9 cells.

Recombinant Human Histone-arginine methyltransferase CARM1(CARM1) - CSB-YP771462HU CSB-EP771462HU CSB-BP771462HU CSB-MP771462HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

CARM1 Blocking Peptide - 3734RBP-50 from Biovision Category Peptide Prices $95.00 Sizes 50 µg

CARM1(Phospho-Ser228) antibody blocking peptide - 51331 from Signalway Antibody Category Peptide Prices $70.00 Sizes 100 µl

CARM1 / PRMT4 - TP317483 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

CARM1, Peptide - MBS843672 from MyBioSource Category Peptide Prices $165.00 Sizes 50 µg

Recombinant Human CARM1 Protein, GST-tagged - CARM1-176H from Creative Biomart Category Protein Source E.coli Species Human

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