Gene Symbol | AKTIP |
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Entrez Gene | 64400 |
Alt Symbol | FT1, FTS |
Species | Human |
Gene Type | protein-coding |
Description | AKT interacting protein |
Other Description | AKT-interacting protein|fused toes homolog|fused toes protein homolog |
Swissprots | Q53H38 Q9H8T0 Q503B1 |
Accessions | CAD10180 EAW82803 EAW82804 EAW82805 EAW82806 EAW82807 EAW82808 EAW82809 Q9H8T0 AK023320 BAB14524 AK098222 AK222743 BAD96463 AK303503 BAG64536 AL133106 CAH56392 BC001134 AAH01134 BC095401 AAH95401 BG568989 BI545474 BM992149 CR457308 CAG33589 HQ448037 ADQ32518 XM_005256094 XP_005256151 XM_005256095 XP_005256152 XM_005256096 XP_005256153 XM_005256097 XP_005256154 XM_005256098 XP_005256155 NM_001012398 NP_001012398 NM_001308325 NP_001295254 NM_022476 NP_071921 |
Function | Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. {ECO:0000269|PubMed:14749367, ECO:0000269|PubMed:18799622}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:14749367}. Cell membrane {ECO:0000269|PubMed:14749367}; Peripheral membrane protein {ECO:0000269|PubMed:14749367}. |
FTS CRISPR/Cas9 KO Plasmid (h) - sc-406459 from Santa Cruz Biotechnology
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FTS HDR Plasmid (h) - sc-406459-HDR from Santa Cruz Biotechnology
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FTS Double Nickase Plasmid (h) - sc-406459-NIC from Santa Cruz Biotechnology
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FTS Double Nickase Plasmid (h2) - sc-406459-NIC-2 from Santa Cruz Biotechnology
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FTS CRISPR Activation Plasmid (h) - sc-406459-ACT from Santa Cruz Biotechnology
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FTS CRISPR Activation Plasmid (h2) - sc-406459-ACT-2 from Santa Cruz Biotechnology
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FTS Lentiviral Activation Particles (h) - sc-406459-LAC from Santa Cruz Biotechnology
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FTS Lentiviral Activation Particles (h2) - sc-406459-LAC-2 from Santa Cruz Biotechnology
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FTS siRNA (h) - sc-93013 from Santa Cruz Biotechnology
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FTS shRNA Plasmid (h) - sc-93013-SH from Santa Cruz Biotechnology
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FTS shRNA (h) Lentiviral Particles - sc-93013-V from Santa Cruz Biotechnology
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FTS RNAi - H00064400-R02 from Novus Biologicals
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FTS RNAi - H00064400-R01 from Novus Biologicals
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MISSION® esiRNA - EHU106831 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3037 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3037 from Sigma-Aldrich
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AKTIP siRNA (Human) - CRJ2005 from Cohesion Biosciences
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AKTIP - MBS8222875 from MyBioSource
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shRNA set against Human AKTIP (NM_022476.2) - SHH234694 from Creative biogene
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shRNA set against Human AKTIP(NM_001012398.1) - SHG051707 from Creative biogene
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Human AKTIP siRNA - orb272506 from Biorbyt
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AKTIP shRNA Plasmid (Human) - CHJ2005 from Cohesion Biosciences
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AKTIP miRNA 3'UTR clone - MiUTR1H-00283 from Creative biogene
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AKTIP miRNA 3'UTR clone - MiUTR3H-10033 from Creative biogene
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