FYN

Gene Symbol	FYN
Entrez Gene	2534
Alt Symbol	SLK, SYN, p59-FYN
Species	Human
Gene Type	protein-coding
Description	FYN proto-oncogene, Src family tyrosine kinase
Other Description	FYN oncogene related to SRC, FGR, YES|OKT3-induced calcium influx regulator|c-syn protooncogene|proto-oncogene Syn|proto-oncogene c-Fyn|src-like kinase|src/yes-related novel|tyrosine kinase p59fyn(T)|tyrosine-protein kinase Fyn
Swissprots	H0UI48 E1P557 Q5R3A7 Q5R3A6 Q16248 B5BU57 P06241 Q8N5D7
Accessions	AAA52491 AAA52492 EAW48278 EAW48279 EAW48280 EAW48281 EAW48282 EAW48283 EAW48284 P06241 AB451293 BAG70107 AB451426 BAG70240 AI187118 AK056699 BAG51788 AY429536 BC032496 AAH32496 BI552534 BP391373 CX781584 CX872011 DA570412 DA815564 DA922886 DA931034 JF432194 ADZ15411 M14333 AAC08285 M14676 AAA36615 S74774 AAB33113 XM_005266890 XP_005266947 XM_005266892 XP_005266949 XM_011535662 XP_011533964 XM_011535663 XP_011533965 XM_011535664 XP_011533966 XM_011535665 XP_011533967 XM_011535666 XP_011533968 XM_011535667 XP_011533969 XM_011535668 XP_011533970 NM_002037 NP_002028 NM_153047 NP_694592 NM_153048 NP_694593 NM_001242779
Function	Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta- catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an esse
Subcellular Location	Cytoplasm. Nucleus. Cell membrane. Note=Present and active in lipid rafts. Palmitoylation is crucial for proper trafficking.
Tissue Specificity	Isoform 1 is highly expressed in the brain. Isoform 2 is expressed in cells of hemopoietic lineages, especially T-lymphocytes. {ECO:0000269|PubMed:10196263}.
Top Pathways	Sphingolipid signaling pathway, Measles, Adherens junction, Osteoclast differentiation, Prion diseases

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Phosphotyrosine FYN / Tyrosine-protein Kinase Fyn ELISA Kit - RAB0965 from Sigma-Aldrich Category ELISA Kit Prices $637.00 Sizes 1 kt

Mouse/Human/Rat Phospho-SYN / FYN (Tyr530) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1134 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.313-20 ng/ml

Mouse/Human/Rat SYN / FYN ELISA Kit (Cell-Based ELISA) - LS-F2003 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.313-20 ng/ml

Mouse SYN / FYN ELISA Kit (Sandwich ELISA) - LS-F7289 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.115 ng/ml Range 0.313-20 ng/ml

Human SYN / FYN ELISA Kit (Sandwich ELISA) - LS-F7527 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.313-20 ng/ml

Human FYN ELISA Kit - abx151604 from Abbexa Category ELISA Kit Sensitivity 0.060 ng/ml Range 0.156 ng/ml - 10 ng/ml

Tyrosine-protein kinase Fyn (FYN), Human, ELISA Kit - CSB-EL009101HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Tyrosine-protein kinase Fyn (FYN), Human, ELISA Kit - E01T0613 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

FYN oncogene related to SRC, FGR, YES, ELISA Kit - MBS912898 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

FYN Oncogene Related To SRC/FGR/YES (FYN), ELISA Kit - MBS2018851 from MyBioSource Category ELISA Kit Prices $385.00, $575.00, $785.00, $3,210.00, $5,825.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.115ng/mL. Range 0.313-20ng/mL

FYN Oncogene Related To SRC/FGR/YES (FYN), ELISA Kit - MBS2022752 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.060ng/mL. Range 0.156-10ng/mL

Fyn Colorimetric Cell-Based ELISA Kit - CB5279 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Fyn (Phospho-Tyr530) Colorimetric Cell-Based ELISA Kit - CBP1118 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Tyrosine protein kinase Fyn (FYN), ELISA Kit - MBS7205481 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase Fyn (FYN), ELISA Kit - MBS7243789 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase Fyn (FYN), ELISA Kit - MBS7229973 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase Fyn (FYN), ELISA Kit - MBS7237667 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase Fyn (FYN), ELISA Kit - MBS7248697 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase Fyn (FYN), ELISA Kit - MBS7235905 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase Fyn (FYN), ELISA Kit - MBS7252034 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase Fyn (FYN), ELISA Kit - MBS7211896 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase Fyn (FYN), ELISA Kit - MBS7203962 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase Fyn (FYN), ELISA Kit - MBS7252415 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase Fyn (FYN), ELISA Kit - MBS7224060 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for FYN Oncogene Related To SRC/FGR/YES (FYN) - SEK247Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.060ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

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