FYN

Gene Symbol	FYN
Entrez Gene	2534
Alt Symbol	SLK, SYN, p59-FYN
Species	Human
Gene Type	protein-coding
Description	FYN proto-oncogene, Src family tyrosine kinase
Other Description	FYN oncogene related to SRC, FGR, YES|OKT3-induced calcium influx regulator|c-syn protooncogene|proto-oncogene Syn|proto-oncogene c-Fyn|src-like kinase|src/yes-related novel|tyrosine kinase p59fyn(T)|tyrosine-protein kinase Fyn
Swissprots	H0UI48 E1P557 Q5R3A7 Q5R3A6 Q16248 B5BU57 P06241 Q8N5D7
Accessions	AAA52491 AAA52492 EAW48278 EAW48279 EAW48280 EAW48281 EAW48282 EAW48283 EAW48284 P06241 AB451293 BAG70107 AB451426 BAG70240 AI187118 AK056699 BAG51788 AY429536 BC032496 AAH32496 BI552534 BP391373 CX781584 CX872011 DA570412 DA815564 DA922886 DA931034 JF432194 ADZ15411 M14333 AAC08285 M14676 AAA36615 S74774 AAB33113 XM_005266890 XP_005266947 XM_005266892 XP_005266949 XM_011535662 XP_011533964 XM_011535663 XP_011533965 XM_011535664 XP_011533966 XM_011535665 XP_011533967 XM_011535666 XP_011533968 XM_011535667 XP_011533969 XM_011535668 XP_011533970 NM_002037 NP_002028 NM_153047 NP_694592 NM_153048 NP_694593 NM_001242779
Function	Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta- catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an esse
Subcellular Location	Cytoplasm. Nucleus. Cell membrane. Note=Present and active in lipid rafts. Palmitoylation is crucial for proper trafficking.
Tissue Specificity	Isoform 1 is highly expressed in the brain. Isoform 2 is expressed in cells of hemopoietic lineages, especially T-lymphocytes. {ECO:0000269|PubMed:10196263}.
Top Pathways	Sphingolipid signaling pathway, Measles, Adherens junction, Osteoclast differentiation, Prion diseases

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® Fyn siRNA I - 12473 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

Fyn CRISPR/Cas9 KO Plasmid (h) - sc-400152 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Fyn HDR Plasmid (h) - sc-400152-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Fyn Double Nickase Plasmid (h) - sc-400152-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Fyn Double Nickase Plasmid (h2) - sc-400152-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Fyn CRISPR Activation Plasmid (h) - sc-400152-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Fyn CRISPR Activation Plasmid (h2) - sc-400152-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Fyn Lentiviral Activation Particles (h) - sc-400152-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Fyn Lentiviral Activation Particles (h2) - sc-400152-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Fyn siRNA (h) - sc-29321 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Fyn shRNA Plasmid (h) - sc-29321-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Fyn shRNA (h) Lentiviral Particles - sc-29321-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Fyn RNAi - H00002534-R04 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

Fyn RNAi - H00002534-R05 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU062491 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® siRNA - SIHK0825 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0824 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0826 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1530 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1530 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04108 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr04108

FYN siRNA (Human) - CRH1679 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Fyn RNAi - H00002534-R06 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

FYN - MBS827846 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human FYN (NM_002037.5) - SHH298029 from Creative biogene Category siRNA Species Reactivities Human

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