FYN

Gene Symbol	FYN
Entrez Gene	2534
Alt Symbol	SLK, SYN, p59-FYN
Species	Human
Gene Type	protein-coding
Description	FYN proto-oncogene, Src family tyrosine kinase
Other Description	FYN oncogene related to SRC, FGR, YES|OKT3-induced calcium influx regulator|c-syn protooncogene|proto-oncogene Syn|proto-oncogene c-Fyn|src-like kinase|src/yes-related novel|tyrosine kinase p59fyn(T)|tyrosine-protein kinase Fyn
Swissprots	H0UI48 E1P557 Q5R3A7 Q5R3A6 Q16248 B5BU57 P06241 Q8N5D7
Accessions	AAA52491 AAA52492 EAW48278 EAW48279 EAW48280 EAW48281 EAW48282 EAW48283 EAW48284 P06241 AB451293 BAG70107 AB451426 BAG70240 AI187118 AK056699 BAG51788 AY429536 BC032496 AAH32496 BI552534 BP391373 CX781584 CX872011 DA570412 DA815564 DA922886 DA931034 JF432194 ADZ15411 M14333 AAC08285 M14676 AAA36615 S74774 AAB33113 XM_005266890 XP_005266947 XM_005266892 XP_005266949 XM_011535662 XP_011533964 XM_011535663 XP_011533965 XM_011535664 XP_011533966 XM_011535665 XP_011533967 XM_011535666 XP_011533968 XM_011535667 XP_011533969 XM_011535668 XP_011533970 NM_002037 NP_002028 NM_153047 NP_694592 NM_153048 NP_694593 NM_001242779
Function	Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta- catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an esse
Subcellular Location	Cytoplasm. Nucleus. Cell membrane. Note=Present and active in lipid rafts. Palmitoylation is crucial for proper trafficking.
Tissue Specificity	Isoform 1 is highly expressed in the brain. Isoform 2 is expressed in cells of hemopoietic lineages, especially T-lymphocytes. {ECO:0000269|PubMed:10196263}.
Top Pathways	Sphingolipid signaling pathway, Measles, Adherens junction, Osteoclast differentiation, Prion diseases

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Fyn full length protein - ab84696 from Abcam Category Protein Prices $302.00, $352.00, $1,845.00 Sizes 5 µg, 10 µg, 100 µg Source Baculovirus infected sf9 cells Species Human

Active human Fyn full length protein - ab135007 from Abcam Category Protein Prices $465.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human Fyn full length protein - ab152402 from Abcam Category Protein Source Wheat germ Species Human

Human Fyn full length protein - ab85650 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human Fyn peptide - ab22784 from Abcam Category Peptide Species Human

Human Fyn protein fragment - ab152403 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human Fyn Protein - H00002534-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Fyn Protein - H00002534-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Fyn Recombinant Protein - P4697 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

Fyn Peptide - P2752 from Novus Biologicals Category Peptide Species Human

FYN-Antibody-N-term-Blocking-Peptide - BP7709d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FYN-Antibody-N-term-Blocking-Peptide - BP7709a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FYN blocking peptide - GTX89744-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Rat, Bovine

p59-Fyn Protein (OPPA01399) - OPPA01399 from Aviva Systems Biology Category Protein Prices $315.00 Sizes 2 µg Source E. Coli

FYN Immunizing peptide - orb17192 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

FYN Blocking Peptide - 33R-3193 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

FYN Blocking Peptide - 33R-1771 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

FYN (phospho-Tyr530) Blocking Peptide - abx062643 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Pig, Zebrafish

FYN Peptide - AC21-0066-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

FYN - H00002534-P01-02 from Acris Antibodies Category Protein Prices $300.00 Sizes 2 µg Source in vitro transl. Species Human

FYN - H00002534-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

FYN - H00002534-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

FYN - P4697 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

FYN Peptide - 45-059P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse

FYN fusion protein - ag11080 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

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