Gene Symbol | VTN |
---|---|
Entrez Gene | 7448 |
Alt Symbol | V75, VN, VNT |
Species | Human |
Gene Type | protein-coding |
Description | vitronectin |
Other Description | S-protein|complement S-protein|epibolin|serum spreading factor|serum-spreading factor|somatomedin B |
Swissprots | Q9BSH7 B2R7G0 P04004 P01141 |
Accessions | AAK60270 ADL14521 AFQ00545 CAA28659 EAW51082 P04004 AI352496 AK298441 BAH12789 AK312968 BAG35807 BC005046 AAH05046 BG470977 BI758517 DQ893394 ABM84320 DQ896716 ABM87715 X03168 CAA26933 NM_000638 NP_000629 |
Function | Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. |
Subcellular Location | Secreted, extracellular space. |
Tissue Specificity | Plasma. |
Top Pathways | Focal adhesion, ECM-receptor interaction, PI3K-Akt signaling pathway, Proteoglycans in cancer |