Gene Symbol | VTN |
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Entrez Gene | 7448 |
Alt Symbol | V75, VN, VNT |
Species | Human |
Gene Type | protein-coding |
Description | vitronectin |
Other Description | S-protein|complement S-protein|epibolin|serum spreading factor|serum-spreading factor|somatomedin B |
Swissprots | Q9BSH7 B2R7G0 P04004 P01141 |
Accessions | AAK60270 ADL14521 AFQ00545 CAA28659 EAW51082 P04004 AI352496 AK298441 BAH12789 AK312968 BAG35807 BC005046 AAH05046 BG470977 BI758517 DQ893394 ABM84320 DQ896716 ABM87715 X03168 CAA26933 NM_000638 NP_000629 |
Function | Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. |
Subcellular Location | Secreted, extracellular space. |
Tissue Specificity | Plasma. |
Top Pathways | Focal adhesion, ECM-receptor interaction, PI3K-Akt signaling pathway, Proteoglycans in cancer |
Vitronectin CRISPR/Cas9 KO Plasmid (h) - sc-401129 from Santa Cruz Biotechnology
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Vitronectin HDR Plasmid (h) - sc-401129-HDR from Santa Cruz Biotechnology
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Vitronectin Double Nickase Plasmid (h) - sc-401129-NIC from Santa Cruz Biotechnology
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Vitronectin Double Nickase Plasmid (h2) - sc-401129-NIC-2 from Santa Cruz Biotechnology
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Vitronectin CRISPR Activation Plasmid (h) - sc-401129-ACT from Santa Cruz Biotechnology
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Vitronectin CRISPR Activation Plasmid (h2) - sc-401129-ACT-2 from Santa Cruz Biotechnology
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Vitronectin Lentiviral Activation Particles (h) - sc-401129-LAC from Santa Cruz Biotechnology
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Vitronectin Lentiviral Activation Particles (h2) - sc-401129-LAC-2 from Santa Cruz Biotechnology
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Vitronectin siRNA (h) - sc-36820 from Santa Cruz Biotechnology
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Vitronectin shRNA Plasmid (h) - sc-36820-SH from Santa Cruz Biotechnology
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Vitronectin shRNA (h) Lentiviral Particles - sc-36820-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU120541 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22755 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22755 from Sigma-Aldrich
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VTN siRNA (Human) - CRH5096 from Cohesion Biosciences
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VTN - MBS8229181 from MyBioSource
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shRNA set against Human VTN (NM_000638.3) - SHH445376 from Creative biogene
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shRNA set against Human VTN(NM_000638.3) - SHL129072 from Creative biogene
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Human VTN siRNA - orb265598 from Biorbyt
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VTN shRNA Plasmid (Human) - CHH5096 from Cohesion Biosciences
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VTN miRNA 3'UTR clone - MiUTR1H-11177 from Creative biogene
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