| Gene Symbol |
MGLL
|
| Entrez Gene |
11343
|
| Alt Symbol |
HU-K5, HUK5, MAGL, MGL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
monoglyceride lipase
|
| Other Description |
lysophospholipase homolog|monoacylglycerol lipase
|
| Swissprots |
Q96AA5 B7Z9D1 B3KRC2 Q6IBG9 Q99685
|
| Accessions |
CBG21711 CBG21792 CBV34969 CBV35050 EAW79329 EAW79330 EAW79331 Q99685 AF131821 AI125141 AI379999 AJ270950 CAC43316 AK025983 AK026389 AK091314 BAG52334 AK093841 AK125135 AK304844 BAH14267 AK310874 AK315529 BAG37910 AL365376 AL833254 AW166623 AY172950 AAO45694 BC000551 AAH00551 BC006230 AAH06230 BC047298 BC073823 BE302457 BG035493 BG249567 BM051374 BM669411 BP307995 BX403703 BX640777 CAE45873 CR456835 CAG33116 DA240965 DQ891955 ABM82881 DQ895141 ABM86067 EU660904 ACD37712 U67963 AAB39616 XM_011512377 XP_011510679 XM_011512378 XP_011510680 XM_011512379 XP_011510681 XM_011512380 XP_011510682 XM_011512381 XP_011510683 XM_011512382 XP_011510684 XM_011512383 XP_011510685 NM_001003794 NP_001003794 NM_001256585 NP_001243514 NM_007283 NP_009214
|
| Function |
Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (PubMed:20079333). {ECO:0000250|UniProtKB:O35678, ECO:0000269|PubMed:20079333}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000250|UniProtKB:O35678}. Membrane {ECO:0000250|UniProtKB:O35678}; Peripheral membrane protein {ECO:0000250|UniProtKB:O35678}.
|
| Tissue Specificity |
Detected in adipose tissue, lung, liver, kidney, brain and heart. {ECO:0000269|PubMed:11470505}.
|
| Top Pathways |
Retrograde endocannabinoid signaling, Glycerolipid metabolism
|