MGLL

Gene Symbol MGLL
Entrez Gene 11343
Alt Symbol HU-K5, HUK5, MAGL, MGL
Species Human
Gene Type protein-coding
Description monoglyceride lipase
Other Description lysophospholipase homolog|monoacylglycerol lipase
Swissprots Q96AA5 B7Z9D1 B3KRC2 Q6IBG9 Q99685
Accessions CBG21711 CBG21792 CBV34969 CBV35050 EAW79329 EAW79330 EAW79331 Q99685 AF131821 AI125141 AI379999 AJ270950 CAC43316 AK025983 AK026389 AK091314 BAG52334 AK093841 AK125135 AK304844 BAH14267 AK310874 AK315529 BAG37910 AL365376 AL833254 AW166623 AY172950 AAO45694 BC000551 AAH00551 BC006230 AAH06230 BC047298 BC073823 BE302457 BG035493 BG249567 BM051374 BM669411 BP307995 BX403703 BX640777 CAE45873 CR456835 CAG33116 DA240965 DQ891955 ABM82881 DQ895141 ABM86067 EU660904 ACD37712 U67963 AAB39616 XM_011512377 XP_011510679 XM_011512378 XP_011510680 XM_011512379 XP_011510681 XM_011512380 XP_011510682 XM_011512381 XP_011510683 XM_011512382 XP_011510684 XM_011512383 XP_011510685 NM_001003794 NP_001003794 NM_001256585 NP_001243514 NM_007283 NP_009214
Function Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (PubMed:20079333). {ECO:0000250|UniProtKB:O35678, ECO:0000269|PubMed:20079333}.
Subcellular Location Cytoplasm, cytosol {ECO:0000250|UniProtKB:O35678}. Membrane {ECO:0000250|UniProtKB:O35678}; Peripheral membrane protein {ECO:0000250|UniProtKB:O35678}.
Tissue Specificity Detected in adipose tissue, lung, liver, kidney, brain and heart. {ECO:0000269|PubMed:11470505}.
Top Pathways Retrograde endocannabinoid signaling, Glycerolipid metabolism

Monoglyceride Lipase CRISPR/Cas9 KO Plasmid (h) - sc-403789 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Monoglyceride Lipase HDR Plasmid (h) - sc-403789-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Monoglyceride Lipase Double Nickase Plasmid (h) - sc-403789-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Monoglyceride Lipase Double Nickase Plasmid (h2) - sc-403789-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Monoglyceride Lipase CRISPR Activation Plasmid (h) - sc-403789-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Monoglyceride Lipase CRISPR Activation Plasmid (h2) - sc-403789-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Monoglyceride Lipase Lentiviral Activation Particles (h) - sc-403789-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Monoglyceride Lipase Lentiviral Activation Particles (h2) - sc-403789-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Monoglyceride Lipase siRNA (h) - sc-72277 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Monoglyceride Lipase shRNA Plasmid (h) - sc-72277-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Monoglyceride Lipase shRNA (h) Lentiviral Particles - sc-72277-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU040691 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN13302 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13302 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MGLL siRNA (Human) - CRH7770 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MGLL shRNA Plasmid (Human) - CHH7770 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MGLL miRNA 3'UTR clone - MiUTR4H-TG05510 from Creative biogene

Species Reactivities Human
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