MGLL

Gene Symbol MGLL
Entrez Gene 11343
Alt Symbol HU-K5, HUK5, MAGL, MGL
Species Human
Gene Type protein-coding
Description monoglyceride lipase
Other Description lysophospholipase homolog|monoacylglycerol lipase
Swissprots Q96AA5 B7Z9D1 B3KRC2 Q6IBG9 Q99685
Accessions CBG21711 CBG21792 CBV34969 CBV35050 EAW79329 EAW79330 EAW79331 Q99685 AF131821 AI125141 AI379999 AJ270950 CAC43316 AK025983 AK026389 AK091314 BAG52334 AK093841 AK125135 AK304844 BAH14267 AK310874 AK315529 BAG37910 AL365376 AL833254 AW166623 AY172950 AAO45694 BC000551 AAH00551 BC006230 AAH06230 BC047298 BC073823 BE302457 BG035493 BG249567 BM051374 BM669411 BP307995 BX403703 BX640777 CAE45873 CR456835 CAG33116 DA240965 DQ891955 ABM82881 DQ895141 ABM86067 EU660904 ACD37712 U67963 AAB39616 XM_011512377 XP_011510679 XM_011512378 XP_011510680 XM_011512379 XP_011510681 XM_011512380 XP_011510682 XM_011512381 XP_011510683 XM_011512382 XP_011510684 XM_011512383 XP_011510685 NM_001003794 NP_001003794 NM_001256585 NP_001243514 NM_007283 NP_009214
Function Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (PubMed:20079333). {ECO:0000250|UniProtKB:O35678, ECO:0000269|PubMed:20079333}.
Subcellular Location Cytoplasm, cytosol {ECO:0000250|UniProtKB:O35678}. Membrane {ECO:0000250|UniProtKB:O35678}; Peripheral membrane protein {ECO:0000250|UniProtKB:O35678}.
Tissue Specificity Detected in adipose tissue, lung, liver, kidney, brain and heart. {ECO:0000269|PubMed:11470505}.
Top Pathways Retrograde endocannabinoid signaling, Glycerolipid metabolism

Monoglyceride Lipase (C-11) - sc-398942 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Monoglyceride Lipase (C-11): sc-398942. Western blot analysis of Monoglyceride Lipase expression in IMR-32 (A) and A2058 (B) whole cell lysates and human lateral ventricle (C) and human adipose (D) tissue extracts.

Monoglyceride Lipase (H-300) - sc-134789 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Monoglyceride Lipase (H-300): sc-134789. Western blot analysis of Monoglyceride Lipase expression in non-transfected: sc-117752 (A) and mouse Monoglyceride Lipase transfected: sc-121714 (B) 293T whole cell lysates and mouse brain tissue extract (C).

Monoglyceride Lipase (M-19) - sc-54110 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Monoglyceride Lipase (S-14) - sc-54111 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Monoacylglycerol Lipase antibody - ab77398 from Abcam

Prices $388.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-Monoacylglycerol Lipase antibody (ab77398) at 0.5 µg/ml + Human Adipose lysate (in RIPA buffer) at 35 µg

Anti-Monoacylglycerol Lipase antibody - ab180016 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Monoacylglycerol Lipase antibody (ab180016) at 1 µg/ml (Milk blocking 3%)Lane 1 : Heart (Human) Tissue Lysate - adult normal tissueLane 2 : Liver (Human) Tissue Lysate - adult normal tissueLane 3 : Adipose (Human) Total Protein Lysate - adult normal tissueLane 4 : Adult Mouse Brown Adipose Tissue Tissue LysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Monoacylglycerol Lipase antibody - ab89824 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-Monoacylglycerol Lipase antibody (ab89824) at 1 µg/ml + human liver tissue lysate at 50 µgdeveloped using the ECL technique

Anti-Monoacylglycerol Lipase antibody - ab130692 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Monoacylglycerol Lipase antibody (ab130692) at 1/100 dilution + A2058 cell line lysates at 35 µgdeveloped using the ECL technique

Anti-Monoacylglycerol Lipase antibody - ab108176 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Monoacylglycerol Lipase antibody (ab108176) at 1 µg/ml + ACHN cell lysate at 10 µg

Anti-Monoacylglycerol Lipase antibody - ab37652 from Abcam

Prices $376.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal
Anti-Monoacylglycerol Lipase antibody (ab37652) at 1/2000 dilution + E coli derived fusion protein at 2.5 µgSecondaryGoat anti IgY HRP at 1/1000 dilutiondeveloped using the ECL technique

Anti-Monoacylglycerol Lipase antibody [1B1] - ab119777 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1B1
Overlay histogram showing HepG2 cells stained with ab119777 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab119777, 1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-Monoacylglycerol Lipase antibody [2B6] - ab119008 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2B6
All lanes : Anti-Monoacylglycerol Lipase antibody [2B6] (ab119008) at 1/2000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY Monoacylglycerol Lipase cDNALysates/proteins at 5 µg per lane.

Anti-Monoacylglycerol Lipase antibody [EPR6339] - ab124796 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6339
Anti-Monoacylglycerol Lipase antibody [EPR6339] (ab124796) at 1/1000 dilution + Human heart lysate at 10 µgSecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-MGLL / Monoacylglycerol Lipase Antibody (clone 2B11) - LS-C337354 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2B11
IHC of paraffin-embedded Carcinoma of Human pancreas tissue using anti-MGLL mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).

Anti-MGLL / Monoacylglycerol Lipase Antibody (clone 4D1) - LS-C173046 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4D1
IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-MGLL mouse monoclonal antibody.

Anti-MGLL / Monoacylglycerol Lipase Antibody (clone 1H1) - LS-C337365 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1H1
IHC of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-MGLL mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).

Anti-MGLL / Monoacylglycerol Lipase Antibody (clone 1A1) - LS-C172965 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1A1
IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-MGLL mouse monoclonal antibody.

Anti-MGLL / Monoacylglycerol Lipase Antibody (aa17-29) IHC-plus™ - LS-B4376 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-MGLL antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4376 concentration 3.75 ug/ml.

Anti-MGLL / Monoacylglycerol Lipase Antibody (clone 1B1) - LS-C173047 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1B1
IHC of paraffin-embedded Human tonsil using anti-MGLL mouse monoclonal antibody.

Anti-MGLL / Monoacylglycerol Lipase Antibody (clone 1C6) - LS-C172967 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1C6
IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-MGLL mouse monoclonal antibody.

Anti-MGLL / Monoacylglycerol Lipase Antibody (clone 2G8) - LS-C172760 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2G8
IHC of paraffin-embedded Carcinoma of Human lung tissue using anti-MGLL mouse monoclonal antibody.

Anti-MGLL / Monoacylglycerol Lipase Antibody (aa1-14) - LS-C11188 from LifeSpan Bioscience

Prices $345.00
Sizes 1 ea
Host Rabbit
Clonality Polyclonal

Anti-MGLL / Monoacylglycerol Lipase Antibody (N-Terminus) - LS-C72766 from LifeSpan Bioscience

Prices $665.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal

Anti-MGLL / Monoacylglycerol Lipase Antibody (N-Terminus) - LS-C117140 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MGLL antibody LS-C117140 Western blot of ACHN lysate.

Anti-MGLL / Monoacylglycerol Lipase Antibody (aa34-63) - LS-C164178 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
MGLL Antibody western blot of A2058 cell line lysates (35 ug/lane). The MGLL antibody detected the MGLL protein (arrow).
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