HOMER1

Gene Symbol HOMER1
Entrez Gene 9456
Alt Symbol HOMER, HOMER1A, HOMER1B, HOMER1C, SYN47, Ves-1
Species Human
Gene Type protein-coding
Description homer scaffolding protein 1
Other Description homer homolog 1|homer protein homolog 1|homer, neuronal immediate early gene, 1|homer-1
Swissprots O96003 Q86YM5 Q86YM7 B2R688
Accessions CAK31441 EAW95835 EAW95836 Q86YM7 AA029302 AF093262 AAC71026 AK223471 BAD97191 AK312481 BAG35385 AY189939 AAO38999 AY189940 AAO39000 AY189941 AAO39001 BC015502 AAH15502 BC047438 AAH47438 BT009846 AAP88848 BU933636 CA396459 CB052446 DQ891278 ABM82204 DQ894466 ABM85392 Y17829 CAA76877 NM_001277077 NP_001264006 NM_001277078 NP_001264007 NM_004272 NP_004263
Function Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.
Subcellular Location Cytoplasm {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum. {ECO:0000250}.
Top Pathways Glutamatergic synapse

Homer1 Antibody - 8231 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from mouse and rat brain tissue using Homer1 Antibody.

Homer (D-3) - sc-17842 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Homer (D-3): sc-17842. Western blot analysis of Homer expression in non-transfected: sc-110760 (A) and human Homer transfected: sc-113176 (B) 293 whole cell lysates and mouse brain tissue extract (C).

Homer (H-342) - sc-15321 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Homer (H-342): sc-15321. Western blot analysis of Homer expression in non-transfected: sc-110760 (A) and human Homer transfected: sc-113176 (B) 293 whole cell lysates and mouse brain tissue extract (C).

Homer-1b/c (B-5) - sc-25271 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Homer-1b/c (B-5): sc-25271. Western blot analysis of Homer isoform expression in BC<sub>3</sub>H1 (A) and L8 (B) whole cell lysates.

Homer-1b/c (C-16) - sc-8923 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Homer-1b/c (C-16): sc-8923. Western blot analysis of Homer-1b/c expression in non-transfected: sc-110760 (A) and human Homer transfected: sc-113176 (B) 293 whole cell lysates.

Homer-1b/c (D-8) - sc-55463 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Homer-1b/c (D-8): sc-55463. Western blot analysis of Homer-1b/c expression in rat brain tissue extract.

Homer-1b/c (H-174) - sc-20807 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Homer-1b/c (H-174): sc-20807. Western blot analysis of Homer-1b/c expression in non-transfected: sc-110760 (A) and human Homer transfected: sc-113176 (B) 293 whole cell lysates and mouse brain tissue extract (C).

Anti-Homer (1b+1c) antibody - ab97593 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Homer (1b+1c) antibody (ab97593) at 1/1000 dilutionLane 1 : H1299 whole cell lysateLane 2 : HepG2 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-Homer (1b+1c) antibody - ab74912 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-Homer antibody - ab104577 from Abcam

Host Goat
Clonality Polyclonal

Anti-Homer antibody - ab135644 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Homer antibody (ab135644) at 1/50 dilution + Mouse bladder tissue lysate at 35 µg

Anti-Homer antibody - ab88827 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-Homer antibody (ab88827) at 1/500 dilution + rat brain tissue lysate at 50 µg

Anti-Homer antibody - ab104505 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Homer antibody (ab104505) at 1/500 dilution + Human Fetal Brain Lysate

Anti-Homer antibody [EPR15309] - ab184955 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR15309
Anti-Homer antibody [EPR15309] (ab184955) at 1/5000 dilution + HepG2 cell lysate at 20 µgSecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-Homer antibody - C-terminal - ab189623 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-Homer antibody - C-terminal (ab189623) at 1/1000 dilution + Mouse brain lysate

Anti-HOMER1 / Homer 1 Antibody (aa101-150) IHC-plus™ - LS-B1538 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-HOMER1 / Homer antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1538 concentration 5 ug/ml.

Anti-HOMER1 / Homer 1 Antibody (aa72-339) IHC-plus™ - LS-B10761 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-HOMER1 / Homer 1 antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10761 concentration 7.5 ug/ml.

Anti-HOMER1 / Homer 1 Antibody (clone AT1F3) - LS-C103482 from LifeSpan Bioscience

Prices $255.00, $315.00
Sizes 50 µl, 100 µl
Host Mouse
Clonality Monoclonal
Clone AT1F3

Anti-HOMER1 / Homer 1 Antibody (aa1-354) - LS-C129879 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-HOMER1 / Homer 1 Antibody - LS-C178412 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HOMER1 / Homer 1 Antibody - LS-C285643 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HOMER1 / Homer 1 Antibody - LS-C308278 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-HOMER1 / Homer 1 Antibody - LS-C310639 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HOMER1 / Homer 1 Antibody (aa281-330) - LS-C30485 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Transfected 293T Cell Lysate

Anti-HOMER1 / Homer 1 Antibody - LS-C308279 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Search more