HOMER1

Gene Symbol	HOMER1
Entrez Gene	9456
Alt Symbol	HOMER, HOMER1A, HOMER1B, HOMER1C, SYN47, Ves-1
Species	Human
Gene Type	protein-coding
Description	homer scaffolding protein 1
Other Description	homer homolog 1|homer protein homolog 1|homer, neuronal immediate early gene, 1|homer-1
Swissprots	O96003 Q86YM5 Q86YM7 B2R688
Accessions	CAK31441 EAW95835 EAW95836 Q86YM7 AA029302 AF093262 AAC71026 AK223471 BAD97191 AK312481 BAG35385 AY189939 AAO38999 AY189940 AAO39000 AY189941 AAO39001 BC015502 AAH15502 BC047438 AAH47438 BT009846 AAP88848 BU933636 CA396459 CB052446 DQ891278 ABM82204 DQ894466 ABM85392 Y17829 CAA76877 NM_001277077 NP_001264006 NM_001277078 NP_001264007 NM_004272 NP_004263
Function	Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.
Subcellular Location	Cytoplasm {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum. {ECO:0000250}.
Top Pathways	Glutamatergic synapse

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Homer full length protein - ab85334 from Abcam Category Protein Source E. coli Species Human

Human Homer full length protein - ab117650 from Abcam Category Protein Source E. coli Species Human

HOMER1 / Homer 1 Antibody Blocking Peptide - LS-E14619 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HOMER1 / Homer 1 Antibody Blocking Peptide - LS-E8845 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HOMER1 Recombinant Protein - H00009456-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human HOMER1 Protein - NBC1-26371 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

HOMER1-Antibody-Center-Blocking-Peptide - BP7302c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HOMER1-Antibody-N-term-Blocking-Peptide - BP7302a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HOMER1 Protein (OPPA02230) - OPPA02230 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human HOMER1 protein - orb245160 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human HOMER1 protein - orb245159 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human HOMER1 protein - orb81165 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

Homer 1 protein (His tag) - 80R-1146 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

HOMER1 Blocking Peptide - 33R-7538 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

HOMER1 Blocking Peptide - 33R-2502 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Homer1 protein (His tag) - 80R-3374 from Fitzgerald Category Protein Prices $210.00 Sizes 50 µg Source E.coli

HOMER1 (1-354, His-tag) - AR09194PU-L from Acris Antibodies Category Protein Prices $785.00 Sizes 500 µg Source E. coli Species Human

HOMER1 (1-354, His-tag) - AR09194PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

HOMER1 - H00009456-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

HOMER1 - H00009456-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Homer Homolog-1, Human Recombinant - 228-10773-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Human

Recombinant Human HOMER1 - 228-10773-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human HOMER1 - 228-10773-3 from RayBiotech Category Protein Prices $3,180.00 Sizes 3 µg Source Escherichia Coli. Species Human

Homer 1, 1- 354 aa, Human, His-tagged, Recombinant, E.coli - 01-2077 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Source E.coli Species Human

HOMER1 fusion protein - Ag3109 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

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