HOMER1

Gene Symbol HOMER1
Entrez Gene 9456
Alt Symbol HOMER, HOMER1A, HOMER1B, HOMER1C, SYN47, Ves-1
Species Human
Gene Type protein-coding
Description homer scaffolding protein 1
Other Description homer homolog 1|homer protein homolog 1|homer, neuronal immediate early gene, 1|homer-1
Swissprots O96003 Q86YM5 Q86YM7 B2R688
Accessions CAK31441 EAW95835 EAW95836 Q86YM7 AA029302 AF093262 AAC71026 AK223471 BAD97191 AK312481 BAG35385 AY189939 AAO38999 AY189940 AAO39000 AY189941 AAO39001 BC015502 AAH15502 BC047438 AAH47438 BT009846 AAP88848 BU933636 CA396459 CB052446 DQ891278 ABM82204 DQ894466 ABM85392 Y17829 CAA76877 NM_001277077 NP_001264006 NM_001277078 NP_001264007 NM_004272 NP_004263
Function Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.
Subcellular Location Cytoplasm {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum. {ECO:0000250}.
Top Pathways Glutamatergic synapse

Homer-1 CRISPR/Cas9 KO Plasmid (h) - sc-401175 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Homer-1 HDR Plasmid (h) - sc-401175-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Homer-1 Double Nickase Plasmid (h) - sc-401175-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Homer-1 Double Nickase Plasmid (h2) - sc-401175-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Homer CRISPR Activation Plasmid (h) - sc-401175-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Homer-1 CRISPR Activation Plasmid (h2) - sc-401175-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Homer-1 Lentiviral Activation Particles (h) - sc-401175-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Homer-1 Lentiviral Activation Particles (h2) - sc-401175-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Homer-1 siRNA (h) - sc-35581 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Homer-1 shRNA Plasmid (h) - sc-35581-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Homer-1 shRNA (h) Lentiviral Particles - sc-35581-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU092371 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10217 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10217 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

HOMER1 siRNA (Human) - CRH6274 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HOMER1 - MBS8240630 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human HOMER1 (NM_004272.3) - SHH313949 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human HOMER1(NM_004272.3) - SHH127847 from Creative biogene

Category siRNA
Species Reactivities Human

HOMER1 shRNA Plasmid (Human) - CHH6274 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

HOMER1 miRNA 3'UTR clone - MiUTR1H-04643 from Creative biogene

Species Reactivities Human
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