| Gene Symbol | HOMER1 |
|---|---|
| Entrez Gene | 9456 |
| Alt Symbol | HOMER, HOMER1A, HOMER1B, HOMER1C, SYN47, Ves-1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | homer scaffolding protein 1 |
| Other Description | homer homolog 1|homer protein homolog 1|homer, neuronal immediate early gene, 1|homer-1 |
| Swissprots | O96003 Q86YM5 Q86YM7 B2R688 |
| Accessions | CAK31441 EAW95835 EAW95836 Q86YM7 AA029302 AF093262 AAC71026 AK223471 BAD97191 AK312481 BAG35385 AY189939 AAO38999 AY189940 AAO39000 AY189941 AAO39001 BC015502 AAH15502 BC047438 AAH47438 BT009846 AAP88848 BU933636 CA396459 CB052446 DQ891278 ABM82204 DQ894466 ABM85392 Y17829 CAA76877 NM_001277077 NP_001264006 NM_001277078 NP_001264007 NM_004272 NP_004263 |
| Function | Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum. {ECO:0000250}. |
| Top Pathways | Glutamatergic synapse |