| Gene Symbol |
WDR48
|
| Entrez Gene |
57599
|
| Alt Symbol |
P80, SPG60, UAF1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
WD repeat domain 48
|
| Other Description |
USP1 associated factor 1|USP1-associated factor 1|WD repeat endosomal protein|WD repeat-containing protein 48
|
| Swissprots |
Q63HJ2 Q9P279 B4DQI2 B4DM86 Q658Y1 Q8TAF3 B4DY84 Q8N3Z1 Q9NSK8
|
| Accessions |
CCQ43651 EAW64548 EAW64549 EAW64550 EAW64551 Q8TAF3 AB040882 BAA95973 AF468833 AAL78650 AK025513 AK074278 AK297349 BAG59798 AK298810 BAG60944 AK302307 BAG63646 AL162064 CAB82402 AL832926 CAH56300 BC012861 BC026353 AAH26353 BC037168 AAH37168 BX649170 CAH56182 DA215447 XM_005265346 XP_005265403 XM_011533971 XP_011532273 XR_940485 NM_001303402 NP_001290331 NM_001303403 NP_001290332 NM_020839 NP_065890
|
| Function |
Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 by enhancing the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12 and USP46, respectively. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP. In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with
|
| Subcellular Location |
Nucleus. Cytoplasm. Lysosome. Note=Mainly cytoplasmic. In case of infection by papillomavirus HPV11, translocates to the nucleus via its interaction with papillomavirus HPV11.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:12196293}.
|
| Top Pathways |
Fanconi anemia pathway
|