WDR48

Gene Symbol WDR48
Entrez Gene 57599
Alt Symbol P80, SPG60, UAF1
Species Human
Gene Type protein-coding
Description WD repeat domain 48
Other Description USP1 associated factor 1|USP1-associated factor 1|WD repeat endosomal protein|WD repeat-containing protein 48
Swissprots Q63HJ2 Q9P279 B4DQI2 B4DM86 Q658Y1 Q8TAF3 B4DY84 Q8N3Z1 Q9NSK8
Accessions CCQ43651 EAW64548 EAW64549 EAW64550 EAW64551 Q8TAF3 AB040882 BAA95973 AF468833 AAL78650 AK025513 AK074278 AK297349 BAG59798 AK298810 BAG60944 AK302307 BAG63646 AL162064 CAB82402 AL832926 CAH56300 BC012861 BC026353 AAH26353 BC037168 AAH37168 BX649170 CAH56182 DA215447 XM_005265346 XP_005265403 XM_011533971 XP_011532273 XR_940485 NM_001303402 NP_001290331 NM_001303403 NP_001290332 NM_020839 NP_065890
Function Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 by enhancing the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12 and USP46, respectively. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP. In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with
Subcellular Location Nucleus. Cytoplasm. Lysosome. Note=Mainly cytoplasmic. In case of infection by papillomavirus HPV11, translocates to the nucleus via its interaction with papillomavirus HPV11.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:12196293}.
Top Pathways Fanconi anemia pathway

WDR48 CRISPR/Cas9 KO Plasmid (h) - sc-412852 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

WDR48 HDR Plasmid (h) - sc-412852-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

WDR48 Double Nickase Plasmid (h) - sc-412852-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

WDR48 Double Nickase Plasmid (h2) - sc-412852-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

WDR48 CRISPR Activation Plasmid (h) - sc-412852-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

WDR48 CRISPR Activation Plasmid (h2) - sc-412852-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

WDR48 Lentiviral Activation Particles (h) - sc-412852-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

WDR48 Lentiviral Activation Particles (h2) - sc-412852-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

WDR48 siRNA (h) - sc-77917 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

WDR48 shRNA Plasmid (h) - sc-77917-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

WDR48 shRNA (h) Lentiviral Particles - sc-77917-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU010281 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22832 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22832 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

WDR48 siRNA (Human) - CRJ1571 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

WDR48 - MBS8224696 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human WDR48 (NM_020839.2) - SHH446240 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human WDR48(NM_020839.2) - SHL131814 from Creative biogene

Category siRNA
Species Reactivities Human

WDR48 shRNA Plasmid (Human) - CHJ1571 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

WDR48 miRNA 3'UTR clone - MiUTR1H-11219 from Creative biogene

Species Reactivities Human
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