WDR48

Gene Symbol	WDR48
Entrez Gene	57599
Alt Symbol	P80, SPG60, UAF1
Species	Human
Gene Type	protein-coding
Description	WD repeat domain 48
Other Description	USP1 associated factor 1|USP1-associated factor 1|WD repeat endosomal protein|WD repeat-containing protein 48
Swissprots	Q63HJ2 Q9P279 B4DQI2 B4DM86 Q658Y1 Q8TAF3 B4DY84 Q8N3Z1 Q9NSK8
Accessions	CCQ43651 EAW64548 EAW64549 EAW64550 EAW64551 Q8TAF3 AB040882 BAA95973 AF468833 AAL78650 AK025513 AK074278 AK297349 BAG59798 AK298810 BAG60944 AK302307 BAG63646 AL162064 CAB82402 AL832926 CAH56300 BC012861 BC026353 AAH26353 BC037168 AAH37168 BX649170 CAH56182 DA215447 XM_005265346 XP_005265403 XM_011533971 XP_011532273 XR_940485 NM_001303402 NP_001290331 NM_001303403 NP_001290332 NM_020839 NP_065890
Function	Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 by enhancing the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12 and USP46, respectively. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP. In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with
Subcellular Location	Nucleus. Cytoplasm. Lysosome. Note=Mainly cytoplasmic. In case of infection by papillomavirus HPV11, translocates to the nucleus via its interaction with papillomavirus HPV11.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:12196293}.
Top Pathways	Fanconi anemia pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human WDR48 full length protein - ab188697 from Abcam Category Protein Prices $572.00 Sizes 50 µg Source Baculovirus infected Sf21 cells Species Human

Human WDR48 full length protein - ab163602 from Abcam Category Protein Source Wheat germ Species Human

WDR48 Antibody Blocking Peptide - LS-E267 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UAF1/WDR48 Recombinant Protein - H00057599-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

WDR48-Antibody-C-term-Blocking-Peptide - BP10505b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human His6-UAF1, CF - E-566-050 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Contains an C-terminal 6-His tag

WDR48 / p80 - H00057599-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

WDR48 / p80 - H00057599-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

WDR48 fusion protein - Ag9674 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human WDR48, GST-tagged - WDR48-3717H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human WD repeat-containing protein 48(WDR48) - CSB-YP851525HU CSB-EP851525HU CSB-BP851525HU CSB-MP851525HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human His6-UAF1 Protein, CF - E-566 from R&D Systems Category Protein Prices $269.00 Sizes 50 µg Source Spodoptera frugiperda , Sf 21 (baculovirus)-derived Contains an C-terminal 6-His tag Species Human

WDR48 Protein - abx163402 from Abbexa Category Protein Species Human, Mouse, Rat

WDR48 / p80 - TP305497 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

WD repeat-containing protein 48 (WDR48) , Recombinant Protein - MBS1348984 from MyBioSource Category Protein Prices $2,525.00, $2,525.00, $2,945.00, $2,945.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

UAF1/WDR48 Recombinant Protein Antigen - NBP1-81404PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

UAF1/WDR48 Recombinant Protein Antigen - NBP2-49269PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

WDR48 Peptide, Human - M34GP17429H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Human WDR48 Protein, MYC/DDK-tagged - WDR48-136H from Creative Biomart Category Protein Source HEK293 Species Human

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