WDR48

Gene Symbol WDR48
Entrez Gene 57599
Alt Symbol P80, SPG60, UAF1
Species Human
Gene Type protein-coding
Description WD repeat domain 48
Other Description USP1 associated factor 1|USP1-associated factor 1|WD repeat endosomal protein|WD repeat-containing protein 48
Swissprots Q63HJ2 Q9P279 B4DQI2 B4DM86 Q658Y1 Q8TAF3 B4DY84 Q8N3Z1 Q9NSK8
Accessions CCQ43651 EAW64548 EAW64549 EAW64550 EAW64551 Q8TAF3 AB040882 BAA95973 AF468833 AAL78650 AK025513 AK074278 AK297349 BAG59798 AK298810 BAG60944 AK302307 BAG63646 AL162064 CAB82402 AL832926 CAH56300 BC012861 BC026353 AAH26353 BC037168 AAH37168 BX649170 CAH56182 DA215447 XM_005265346 XP_005265403 XM_011533971 XP_011532273 XR_940485 NM_001303402 NP_001290331 NM_001303403 NP_001290332 NM_020839 NP_065890
Function Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 by enhancing the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12 and USP46, respectively. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP. In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with
Subcellular Location Nucleus. Cytoplasm. Lysosome. Note=Mainly cytoplasmic. In case of infection by papillomavirus HPV11, translocates to the nucleus via its interaction with papillomavirus HPV11.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:12196293}.
Top Pathways Fanconi anemia pathway

WDR48 (E-4) - sc-514473 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
WDR48 (E-4): sc-514473. Western blot analysis of WDR48 expression in T98G (A), Y79 (B), RT-4 (C), U-251-MG (D) and HEK293 (E) whole cell lysates.

WDR48 (K-14) - sc-99718 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-WDR48 antibody - ab122473 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-WDR48 antibody (ab122473) at 1/100 dilutionLane 1 : NIH-3T3 cell lysate (Mouse embryonic cells)Lane 2 : NBT-II cell lysate (Rat Wistar bladder tumour cells)

Anti-WDR48 Antibody (aa610-638, AP) - LS-C273516 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WDR48 Antibody (aa610-638, APC) - LS-C273518 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WDR48 Antibody (aa610-638, Biotin) - LS-C273519 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WDR48 Antibody (aa610-638, Azide-free, HRP) - LS-C273521 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WDR48 Antibody (aa610-638, FITC) - LS-C273520 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WDR48 Antibody (aa610-638) - LS-C326337 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WDR48 Antibody (aa610-638, PE) - LS-C273522 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WDR48 Antibody (aa603-630) IHC-plus™ - LS-B11223 from LifeSpan Bioscience

Prices $395.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-WDR48 antibody IHC staining of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B11223 dilution 1:100.

UAF1/WDR48 Antibody - NBP1-81404 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: UAF1/WDR48 Antibody [NBP1-81404] - Staining of human cell line A-431 shows localization to vesicles.

ANTI-WDR48 (C-TERM) antibody produced in rabbit - SAB1303456 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>WDR48 (C-term): <B>Cat. No. SAB1303456</B>: WDR48 in Human brain tissue with WDR48 antibody (C-term) at 12.5 μg/mL.

WDR48 Antibody - C-terminal region (OAAB00518) - OAAB00518 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

WDR48-Antibody-C-term - AP10505b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
WDR48 Antibody (C-term) (Cat. #AP10505b) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the WDR48 antibody detected the WDR48 protein (arrow).

WDR48 antibody - orb28410 from Biorbyt

Prices $187.00, $383.00
Sizes 80 μl (Trial size), 400 μl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin fixed and paraffin embedded human brain tissue using WDR48 antibody

WDR48 Antibody - abx025748 from Abbexa

Host Rabbit
Clonality Polyclonal

WDR48 / p80 (C-term) antibody - AP54546PU-N from Acris Antibodies

Prices $330.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
WDR48 antibody (C-term) (AP54546PU-N) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the WDR48 antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Rabbit Anti-Human WDR48 (C-term) - 102-10677 from RayBiotech

Host Rabbit
WDR48 Antibody (C-term) (Cat# 102-10677) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the WDR48 antibody detected the WDR48 protein (arrow).

WDR48 antibody (C-term) - STJ40865 from St John's Laboratory Ltd

Host Rabbit
Clonality Polyclonal
Clone RB28145

Anti-WDR48 antibody - STJ28936 from St John's Laboratory Ltd

Host Rabbit
Clonality Polyclonal

WDR48 antibody - 16503-1-AP from Proteintech Group

Prices $279.00
Sizes con: 34 μg/150μl
Host Rabbit
Clonality Polyclonal
Jurkat cells were subjected to SDS PAGE followed by western blot with 16503-1-AP( WDR48 Antibody) at dilution of 1:600

Anti-WDR48 monoclonal antibody - DCABH-201716 from Creative Diagnostics

Host Rabbit
Clonality Monoclonal

Anti-WDR48 (aa 362-450) polyclonal antibody - DPABH-20772 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

WDR48 Polyclonal Antibody - PA5-24007 from Thermo Fisher Scientific

Prices $349.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Flow cytometry analysis of 293 cells using a WDR48 polyclonal antibody (Product # PA5-24007) (right) compared to a negative control cell (left) at a dilution of 1:10-50, followed by a FITC-conjugated goat anti-rabbit antibody
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