| Gene Symbol |
HIP1R
|
| Entrez Gene |
9026
|
| Alt Symbol |
HIP12, HIP3, ILWEQ
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
huntingtin interacting protein 1 related
|
| Other Description |
HIP-12|HIP1-related protein|huntingtin interacting protein 12|huntingtin-interacting protein 1-related protein|huntingtin-interacting protein 12
|
| Swissprots |
A6NHQ6 Q9UED9 O75146 Q6NXG8
|
| Accessions |
EAW98346 EAW98347 O75146 AB013384 BAA33713 AB014555 BAA31630 AK024062 BAG51260 AK090537 BAG52180 AK295389 BAG58343 AK298387 BAG60622 AK307446 AK308538 AW962010 BC011354 BC038981 BC067085 AAH67085 CF454957 DA779723 DN999807 HY123489 XM_011538963 XP_011537265 XM_011538964 XP_011537266 NM_001303097 NP_001290026 NM_001303099 NP_001290028 NM_003959 NP_003950
|
| Function |
Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3- phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. {ECO:0000269|PubMed:11889126, ECO:0000269|PubMed:14732715}.
|
| Subcellular Location |
Cytoplasm, perinuclear region. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Note=Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region.
|
| Tissue Specificity |
Brain, heart, kidney, pancreas, and liver, but not in lung or placenta.
|