Gene Symbol | HIP1R |
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Entrez Gene | 9026 |
Alt Symbol | HIP12, HIP3, ILWEQ |
Species | Human |
Gene Type | protein-coding |
Description | huntingtin interacting protein 1 related |
Other Description | HIP-12|HIP1-related protein|huntingtin interacting protein 12|huntingtin-interacting protein 1-related protein|huntingtin-interacting protein 12 |
Swissprots | A6NHQ6 Q9UED9 O75146 Q6NXG8 |
Accessions | EAW98346 EAW98347 O75146 AB013384 BAA33713 AB014555 BAA31630 AK024062 BAG51260 AK090537 BAG52180 AK295389 BAG58343 AK298387 BAG60622 AK307446 AK308538 AW962010 BC011354 BC038981 BC067085 AAH67085 CF454957 DA779723 DN999807 HY123489 XM_011538963 XP_011537265 XM_011538964 XP_011537266 NM_001303097 NP_001290026 NM_001303099 NP_001290028 NM_003959 NP_003950 |
Function | Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3- phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. {ECO:0000269|PubMed:11889126, ECO:0000269|PubMed:14732715}. |
Subcellular Location | Cytoplasm, perinuclear region. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Note=Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region. |
Tissue Specificity | Brain, heart, kidney, pancreas, and liver, but not in lung or placenta. |
HIP1 Related RNAi - H00009026-R01 from Novus Biologicals
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MISSION® esiRNA - EHU119971 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10043 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10043 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08792 from Sigma-Aldrich
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HIP1R siRNA (Human) - CRH5953 from Cohesion Biosciences
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HIP12 CRISPR/Cas9 KO Plasmid (h) - sc-405552 from Santa Cruz Biotechnology
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HIP12 HDR Plasmid (h) - sc-405552-HDR from Santa Cruz Biotechnology
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HIP12 Double Nickase Plasmid (h) - sc-405552-NIC from Santa Cruz Biotechnology
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HIP12 Double Nickase Plasmid (h2) - sc-405552-NIC-2 from Santa Cruz Biotechnology
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HIP12 CRISPR Activation Plasmid (h) - sc-405552-ACT from Santa Cruz Biotechnology
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HIP12 CRISPR Activation Plasmid (h2) - sc-405552-ACT-2 from Santa Cruz Biotechnology
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HIP12 Lentiviral Activation Particles (h) - sc-405552-LAC from Santa Cruz Biotechnology
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HIP12 Lentiviral Activation Particles (h2) - sc-405552-LAC-2 from Santa Cruz Biotechnology
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HIP12 siRNA (h) - sc-105453 from Santa Cruz Biotechnology
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HIP12 shRNA Plasmid (h) - sc-105453-SH from Santa Cruz Biotechnology
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HIP12 shRNA (h) Lentiviral Particles - sc-105453-V from Santa Cruz Biotechnology
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HIP1 Related RNAi - H00009026-R02 from Novus Biologicals
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HIP1R - MBS829444 from MyBioSource
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shRNA set against Human HIP1R (NM_003959.1) - SHH312269 from Creative biogene
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HIP1R shRNA Plasmid (Human) - CHH5953 from Cohesion Biosciences
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HIP1R miRNA 3'UTR clone - MiUTR1H-04505 from Creative biogene
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