Gene Symbol | MXD4 |
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Entrez Gene | 10608 |
Alt Symbol | MAD4, MST149, MSTP149, bHLHc12 |
Species | Human |
Gene Type | protein-coding |
Description | MAX dimerization protein 4 |
Other Description | Mad4 homolog|class C basic helix-loop-helix protein 12|max dimerization protein 4|max dimerizer 4|max-associated protein 4|max-interacting transcriptional repressor MAD4 |
Swissprots | A2A335 Q5TZX4 Q14582 |
Accessions | CAA89217 EAW82530 EAW82531 EAW82532 EAW82533 EAW82534 EAW82535 EAW82536 Q14582 AF040963 AAB97009 AF082740 AAF98553 AF187724 AAQ13695 AK024501 BAB15791 AK026392 BC002713 AAH02713 BC028340 BC068060 AAH68060 BT019969 AAV38772 BT019970 AAV38773 XM_011513388 XP_011511690 XM_011513389 XP_011511691 XM_011513390 XP_011511692 XR_427467 XR_924911 XR_924912 NM_006454 NP_006445 |
Function | Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981}. |
Mad 4 CRISPR/Cas9 KO Plasmid (h) - sc-404571 from Santa Cruz Biotechnology
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Mad 4 HDR Plasmid (h) - sc-404571-HDR from Santa Cruz Biotechnology
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Mad 4 Double Nickase Plasmid (h) - sc-404571-NIC from Santa Cruz Biotechnology
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Mad 4 Double Nickase Plasmid (h2) - sc-404571-NIC-2 from Santa Cruz Biotechnology
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Mad 4 CRISPR Activation Plasmid (h) - sc-404571-ACT from Santa Cruz Biotechnology
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Mad 4 CRISPR Activation Plasmid (h2) - sc-404571-ACT-2 from Santa Cruz Biotechnology
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Mad 4 Lentiviral Activation Particles (h) - sc-404571-LAC from Santa Cruz Biotechnology
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Mad 4 Lentiviral Activation Particles (h2) - sc-404571-LAC-2 from Santa Cruz Biotechnology
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Mad 4 siRNA (h) - sc-38077 from Santa Cruz Biotechnology
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Mad 4 shRNA Plasmid (h)-SH - sc-38077-SH from Santa Cruz Biotechnology
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Mad 4 shRNA (h) Lentiviral Particles - sc-38077-V from Santa Cruz Biotechnology
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MAD4 RNAi - H00010608-R01 from Novus Biologicals
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MISSION® esiRNA - EHU113721 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14783 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14783 from Sigma-Aldrich
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MXD4 siRNA (Human) - CRH7221 from Cohesion Biosciences
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shRNA set against Human MXD4 (NM_006454.2) - SHH347328 from Creative biogene
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shRNA set against Human MXD4(NM_006454.2) - SHH209783 from Creative biogene
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Human MXD4 siRNA - orb267723 from Biorbyt
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MXD4 shRNA Plasmid (Human) - CHH7221 from Cohesion Biosciences
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MXD4 miRNA 3'UTR clone - MiUTR1H-06544 from Creative biogene
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