| Gene Symbol |
MAPKAPK5
|
| Entrez Gene |
8550
|
| Alt Symbol |
MAPKAP-K5, MK-5, MK5, PRAK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mitogen-activated protein kinase-activated protein kinase 5
|
| Other Description |
MAP kinase-activated protein kinase 5|MAPK-activated protein kinase 5|MAPKAP kinase 5|MAPKAPK-5|p38-regulated/activated protein kinase
|
| Swissprots |
Q86X46 B3KVA5 Q9UG86 Q9BVX9 O60491 Q8IW41
|
| Accessions |
AAC39863 EAW97979 EAW97980 EAW97981 Q8IW41 AK122767 BAG53717 AL110301 CAB53747 AW780199 BC000833 AAH00833 BC041049 AAH41049 BC047284 AAH47284 BG502445 XM_005253979 XP_005254036 XM_011538909 XP_011537211 XM_011538910 XP_011537212 XM_011538911 XP_011537213 XM_011538912 XP_011537214 XM_011538913 XP_011537215 XM_011538914 XP_011537216 XM_011538915 XP_011537217 XM_011538916 XP_011537218 XM_011538917 XP_011537219 XM_011538918 XP_011537220 XM_011538919 XP_011537221 XM_011538920 XP_011537222 XM_011538921 XP_011537223 XM_011538922 XP_011537224 XR_944806 XR_944807 NM_003668 NP_003659 NM_139078 NP_620777
|
| Function |
Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras- induced senescence and phosphorylating p53/TP53. Involved in post- transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ER
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following phosphorylation and activation. Interaction with ERK3/MAPK6 or ERK4/MAPK4 and phosphorylation at Thr-182, activates the protein kinase activity, followed by translocation to the cytoplasm. Phosphorylation by PKA/PRKACA at Ser-115 also induces nuclear export.
|
| Tissue Specificity |
Expressed ubiquitously. {ECO:0000269|PubMed:9628874}.
|
| Top Pathways |
MAPK signaling pathway
|