MAPKAPK5

Gene Symbol	MAPKAPK5
Entrez Gene	8550
Alt Symbol	MAPKAP-K5, MK-5, MK5, PRAK
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase-activated protein kinase 5
Other Description	MAP kinase-activated protein kinase 5|MAPK-activated protein kinase 5|MAPKAP kinase 5|MAPKAPK-5|p38-regulated/activated protein kinase
Swissprots	Q86X46 B3KVA5 Q9UG86 Q9BVX9 O60491 Q8IW41
Accessions	AAC39863 EAW97979 EAW97980 EAW97981 Q8IW41 AK122767 BAG53717 AL110301 CAB53747 AW780199 BC000833 AAH00833 BC041049 AAH41049 BC047284 AAH47284 BG502445 XM_005253979 XP_005254036 XM_011538909 XP_011537211 XM_011538910 XP_011537212 XM_011538911 XP_011537213 XM_011538912 XP_011537214 XM_011538913 XP_011537215 XM_011538914 XP_011537216 XM_011538915 XP_011537217 XM_011538916 XP_011537218 XM_011538917 XP_011537219 XM_011538918 XP_011537220 XM_011538919 XP_011537221 XM_011538920 XP_011537222 XM_011538921 XP_011537223 XM_011538922 XP_011537224 XR_944806 XR_944807 NM_003668 NP_003659 NM_139078 NP_620777
Function	Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras- induced senescence and phosphorylating p53/TP53. Involved in post- transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ER
Subcellular Location	Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following phosphorylation and activation. Interaction with ERK3/MAPK6 or ERK4/MAPK4 and phosphorylation at Thr-182, activates the protein kinase activity, followed by translocation to the cytoplasm. Phosphorylation by PKA/PRKACA at Ser-115 also induces nuclear export.
Tissue Specificity	Expressed ubiquitously. {ECO:0000269|PubMed:9628874}.
Top Pathways	MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PRAK full length protein - ab125743 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Human PRAK full length protein - ab160089 from Abcam Category Protein Source Wheat germ Species Human

Human PRAK protein fragment - ab160090 from Abcam Category Protein Source Wheat germ Species Human

MAPKAPK5 / PRAK Antibody Blocking Peptide - LS-E8772 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAPKAPK5 / PRAK Antibody Blocking Peptide - LS-E7284 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAPKAPK5 / PRAK Antibody Blocking Peptide - LS-E28033 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAPKAPK5 / PRAK Antibody Blocking Peptide - LS-E28034 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRAK Recombinant Protein - H00008550-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PRAK Partial Recombinant Protein - H00008550-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human PRAK Protein - P4718 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Source E. coli Species Human

PRAK Peptide - P2384 from Novus Biologicals Category Peptide Species Human

PRAK Peptide - P1345 from Novus Biologicals Category Peptide Species Human

Phospho-MAPKAPK5S93-Antibody-Blocking-peptide - BP3151a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

PRAK-MAPKAPK5-Antibody-T182-Blocking-peptide - BP7216a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human MAPKAPK5 protein (GST Tag) - orb139318 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Baculovirus-Insect Cells Species Human

PRAK Peptide - AC21-2909-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PRAK Peptide - AC21-2910-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

MAPKAP Kinase-5 - H00008550-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MAPKAP Kinase-5 - H00008550-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MAPKAP Kinase-5 - H00008550-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MAPKAP Kinase-5 - H00008550-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MAPKAP Kinase-5 - P4718 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

MAPKAP Kinase-5 - P5777 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

MAPKAPK5 fusion protein - ag5913 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

MAPKAPK5 fusion protein - Ag5650 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

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