MAPKAPK5

Gene Symbol	MAPKAPK5
Entrez Gene	8550
Alt Symbol	MAPKAP-K5, MK-5, MK5, PRAK
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase-activated protein kinase 5
Other Description	MAP kinase-activated protein kinase 5|MAPK-activated protein kinase 5|MAPKAP kinase 5|MAPKAPK-5|p38-regulated/activated protein kinase
Swissprots	Q86X46 B3KVA5 Q9UG86 Q9BVX9 O60491 Q8IW41
Accessions	AAC39863 EAW97979 EAW97980 EAW97981 Q8IW41 AK122767 BAG53717 AL110301 CAB53747 AW780199 BC000833 AAH00833 BC041049 AAH41049 BC047284 AAH47284 BG502445 XM_005253979 XP_005254036 XM_011538909 XP_011537211 XM_011538910 XP_011537212 XM_011538911 XP_011537213 XM_011538912 XP_011537214 XM_011538913 XP_011537215 XM_011538914 XP_011537216 XM_011538915 XP_011537217 XM_011538916 XP_011537218 XM_011538917 XP_011537219 XM_011538918 XP_011537220 XM_011538919 XP_011537221 XM_011538920 XP_011537222 XM_011538921 XP_011537223 XM_011538922 XP_011537224 XR_944806 XR_944807 NM_003668 NP_003659 NM_139078 NP_620777
Function	Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras- induced senescence and phosphorylating p53/TP53. Involved in post- transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ER
Subcellular Location	Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following phosphorylation and activation. Interaction with ERK3/MAPK6 or ERK4/MAPK4 and phosphorylation at Thr-182, activates the protein kinase activity, followed by translocation to the cytoplasm. Phosphorylation by PKA/PRKACA at Ser-115 also induces nuclear export.
Tissue Specificity	Expressed ubiquitously. {ECO:0000269|PubMed:9628874}.
Top Pathways	MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PRAK CRISPR/Cas9 KO Plasmid (h) - sc-403215 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PRAK HDR Plasmid (h) - sc-403215-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PRAK Double Nickase Plasmid (h) - sc-403215-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PRAK Double Nickase Plasmid (h2) - sc-403215-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PRAK CRISPR Activation Plasmid (h) - sc-403215-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PRAK CRISPR Activation Plasmid (h2) - sc-403215-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PRAK Lentiviral Activation Particles (h) - sc-403215-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PRAK Lentiviral Activation Particles (h2) - sc-403215-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PRAK siRNA (h) - sc-36310 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PRAK shRNA Plasmid (h) - sc-36310-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PRAK shRNA (h) Lentiviral Particles - sc-36310-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PRAK RNAi - H00008550-R03 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

PRAK RNAi - H00008550-R04 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU016411 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® siRNA - SIHK1234 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1236 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1235 from Sigma-Aldrich Category siRNA

CompoZr® Knockout ZFN Kit - CKOZFN2169 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2169 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03385 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr03385

MAPKAPK5 siRNA (Human) - CRH5621 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human MAPKAPK5 (NM_003668.2) - SHH338171 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human MAPKAPK5(NM_139078.1) - SHH176591 from Creative biogene Category siRNA Species Reactivities Human

Human MAPKAPK5 siRNA - orb266123 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

MAPKAPK5 shRNA Plasmid (Human) - CHH5621 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

Search more