| Gene Symbol |
MTAP
|
| Entrez Gene |
4507
|
| Alt Symbol |
BDMF, DMSFH, DMSMFH, HEL-249, LGMBF, MSAP, c86fus
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
methylthioadenosine phosphorylase
|
| Other Description |
5'-methylthioadenosine phosphorylase|MTA phosphorylase|MTAPase|MeSAdo phosphorylase|S-methyl-5'-thioadenosine phosphorylase|epididymis luminal protein 249
|
| Swissprots |
Q5T3P3 Q9H010 I2G7M5 I2G7N0 I2G7M7 I2G7M9 Q13126 I2G7M8 I2G7M6
|
| Accessions |
AAR24607 BAD60918 EAW58605 EAW58606 Q13126 AB062485 BAB93510 AF109294 AAD19641 AF216650 AAF82688 AK024734 AK300592 BAG62290 AK309365 AY712791 AAU04442 BC012316 AAH12316 BC018625 AAH18625 BC026106 AAH26106 BG576334 BM994282 BQ220538 BQ232183 CA440131 CR541670 CAG46471 CR541710 CAG46511 FJ224338 ACI46030 HE654772 CCF77345 HE654773 CCF77346 HE654774 CCF77347 HE654775 CCF77348 HE654776 CCF77349 HE654777 CCF77350 JF432462 ADZ15679 L40432 AAG38871 U22233 AAA81646 NM_002451 NP_002442
|
| Function |
Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates. {ECO:0000255|HAMAP-Rule:MF_03155, ECO:0000269|PubMed:3091600}.
|
| Subcellular Location |
Cytoplasm. Nucleus {ECO:0000255|HAMAP- Rule:MF_03155}.
|
| Tissue Specificity |
Ubiquitously expressed.
|
| Top Pathways |
Cysteine and methionine metabolism
|
![Western Blot: MTAP Overexpression Lysate (Adult Normal) [NBP2-08113] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MTAP.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/14573_MTAP%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-08113-img0001.jpg)