MTAP

Gene Symbol MTAP
Entrez Gene 4507
Alt Symbol BDMF, DMSFH, DMSMFH, HEL-249, LGMBF, MSAP, c86fus
Species Human
Gene Type protein-coding
Description methylthioadenosine phosphorylase
Other Description 5'-methylthioadenosine phosphorylase|MTA phosphorylase|MTAPase|MeSAdo phosphorylase|S-methyl-5'-thioadenosine phosphorylase|epididymis luminal protein 249
Swissprots Q5T3P3 Q9H010 I2G7M5 I2G7N0 I2G7M7 I2G7M9 Q13126 I2G7M8 I2G7M6
Accessions AAR24607 BAD60918 EAW58605 EAW58606 Q13126 AB062485 BAB93510 AF109294 AAD19641 AF216650 AAF82688 AK024734 AK300592 BAG62290 AK309365 AY712791 AAU04442 BC012316 AAH12316 BC018625 AAH18625 BC026106 AAH26106 BG576334 BM994282 BQ220538 BQ232183 CA440131 CR541670 CAG46471 CR541710 CAG46511 FJ224338 ACI46030 HE654772 CCF77345 HE654773 CCF77346 HE654774 CCF77347 HE654775 CCF77348 HE654776 CCF77349 HE654777 CCF77350 JF432462 ADZ15679 L40432 AAG38871 U22233 AAA81646 NM_002451 NP_002442
Function Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates. {ECO:0000255|HAMAP-Rule:MF_03155, ECO:0000269|PubMed:3091600}.
Subcellular Location Cytoplasm. Nucleus {ECO:0000255|HAMAP- Rule:MF_03155}.
Tissue Specificity Ubiquitously expressed.
Top Pathways Cysteine and methionine metabolism

MTAP Antibody - 4158 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HT29 and NIH/3T3 cells using MTAP Antibody.

MTAP (N-20) - sc-17015 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MTAP (N-20): sc-17015. Western blot analysis of MTAP expression in NIH/3T3 whole cell lysate.

MTAP (C-20) - sc-17017 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MTAP (C-20): sc-17017. Immunoperoxidase staining of formalin fixed, paraffin-embedded human pancreas tissue showing cytoplasmic and nuclear staining of exocrine glandular cells and Islets of Langerhans.

MTAP (FL-283) - sc-292380 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

MTAP (42-T) - sc-100782 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
MTAP (42-T): sc-100782. Western blot analysis of MTAP expression in non-transfected 293T: sc-117752 (A), mouse MTAP transfected 293T: sc-125650 (B) and NIH/3T3 (C) whole cell lysates.

Anti-MTAP antibody - ab196597 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MTAP antibody (ab196597) at 1/500 dilutionLane 1 : HT29 cell lysateLane 2 : Liver cell lysate

Anti-MTAP antibody - ab55517 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-MTAP antibody - ab96231 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-MTAP antibody (ab96231) at 1/1000 dilution + A431 whole cell lysate at 30 µg

Anti-MTAP antibody - ab186905 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-MTAP antibody (ab186905) at 1 µg/ml + Jurkat whole cell lysate at 10 µg

Anti-MTAP antibody [EPR6892] - ab126623 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6892
All lanes : Anti-MTAP antibody [EPR6892] (ab126623) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : Human heart lysateLane 3 : C6 cell lysateLane 4 : RAW 264.7 cell lysateLane 5 : NIH 3T3 cell lysateLane 6 : HT29 cell lysateLysates/proteins at 10 µg per lane.SecondaryStandard HRP labelled goat anti-rabbit at 1/2000 dilutiondeveloped using the ECL technique

Anti-MTAP antibody [EPR6893] - ab126770 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6893
Overlay histogram showing HeLa cells stained with ab126770 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab126770, 1/100 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-MTAP antibody - N-terminal - ab156418 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-MTAP antibody - N-terminal (ab156418) at 1/100 dilution + MDA-MB453 cell line lysates at 35 µg

Anti-MTAP Antibody (aa1-283) - LS-C186047 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded SAS xenograft using MTAP antibody at 1:500 dilution.

Anti-MTAP Antibody - LS-C331222 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of HeLa cell using MTAP antibody. Blue: DAPI for nuclear staining.

Anti-MTAP Antibody (clone 2G4) - LS-C197712 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2G4
Immunofluorescence of monoclonal antibody to MTAP on HeLa cell. [antibody concentration 10 ug/ml]

Anti-MTAP Antibody (Internal, clone EPR6892) - LS-C152284 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6892
Western blot analysis on (A) HeLa, (B) human heart, (C) C6, (D) RAW 264.7, (E) NIH/3T3, and (F) HT-29 cell lysates using anti-MTAP antibody.

Anti-MTAP Antibody (aa8-37, AP) - LS-C207278 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MTAP Antibody (aa8-37, APC) - LS-C208966 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MTAP Antibody (aa8-37, Biotin) - LS-C208967 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MTAP Antibody (aa8-37, FITC) - LS-C208968 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MTAP Antibody (aa8-37, PE) - LS-C208970 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MTAP Antibody (aa8-37, Azide-free, HRP) - LS-C208969 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MTAP Antibody (aa8-37) - LS-C323145 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MTAP Antibody (aa1-155, Azide-free) - LS-C327815 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-MTAP Antibody (aa8-37) - LS-C157973 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
MTAP Antibody western blot of MDA-MB453 cell line lysates (35 ug/lane). The MTAP antibody detected the MTAP protein (arrow).
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