SH2D2A

Gene Symbol	SH2D2A
Entrez Gene	9047
Alt Symbol	F2771, SCAP, TSAD, VRAP
Species	Human
Gene Type	protein-coding
Description	SH2 domain containing 2A
Other Description	SH2 domain protein 2A|SH2 domain-containing protein 2A|T cell specific adapter protein TSAd|T lymphocyte specific adaptor protein|VEGF receptor-associated protein
Swissprots	Q5UBZ1 O43817 Q5VZS4 Q9NP31 Q5VZS5 Q9UPA7
Accessions	AAF69027 EAW52905 EAW52906 EAW52907 Q9NP31 AF051325 AAC99298 AF097744 AAF43260 AJ000553 CAA04185 AK222737 BAD96457 AK313706 BAG36451 AY763098 AAV34673 AY763099 AAV34674 AY763100 AAV34675 BC012107 AAH12107 BQ012931 DB128222 EU832614 ACE87705 EU832686 ACE87018 XM_006711615 XP_006711678 XM_011510113 XP_011508415 XM_011510114 XP_011508416 XM_011510115 XP_011508417 NM_001161441 NP_001154913 NM_001161442 NP_001154914 NM_001161443 NP_001154915 NM_001161444 NP_001154916 NM_003975 NP_003966
Function	Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56- LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation.
Subcellular Location	Cytoplasm.
Tissue Specificity	Expression limited to tissues of the immune system and, in particular, activated T-cells. Expressed in peripheral blood leukocytes, thymus and spleen. Much lower expression or undetectable, in brain, placenta, skeletal muscle, prostate, testis, ovary, small intestine, and colon. Expressed at low levels in unstimulated T-cells, but not expressed in normal resting or activated B-cells. According to PubMed:10692392, expression is not restricted to activated T-cells, but strongly expressed in blood cell lineages, the endothelium and other cell and tissue types, such as heart, lung, and liver.
Top Pathways	VEGF signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Lad (L-16) - sc-28522 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Lad (I-20) - sc-28523 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-SH2D2A antibody - ab103772 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-SH2D2A antibody - ab138037 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SH2D2A antibody - ab67262 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-SH2D2A Antibody (aa279-389) - LS-C132064 from LifeSpan Bioscience Prices $605.00 Sizes 100 µg Host Sheep Clonality Polyclonal

Anti-SH2D2A Antibody (aa86-112, APC) - LS-C269259 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SH2D2A Antibody (aa86-112, AP) - LS-C269258 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SH2D2A Antibody (clone 4F3) - LS-C173781 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 4F3

Anti-SH2D2A Antibody (aa86-112, FITC) - LS-C269261 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SH2D2A Antibody (aa86-112, Azide-free, HRP) - LS-C269262 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SH2D2A Antibody (aa86-112, PE) - LS-C269263 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SH2D2A Antibody (aa200-249) - LS-C200664 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SH2D2A Antibody (aa94-124) - LS-C325076 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SH2D2A Antibody (aa211-260) - LS-C120388 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SH2D2A Antibody (aa86-112) - LS-C169055 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-SH2D2A Antibody (clone 1B8) - LS-C337654 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1B8

Anti-SH2D2A Antibody - LS-C332506 from LifeSpan Bioscience Prices $305.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SH2D2A Antibody (clone 6G1) - LS-C173826 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 6G1

Anti-SH2D2A Antibody (clone 3C7) - LS-C173786 from LifeSpan Bioscience Prices $350.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 3C7

Anti-SH2D2A Antibody (aa86-112, Biotin) - LS-C269260 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

SH2D2A Antibody (4F3) - NBP2-01828 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 4F3

SH2D2A Antibody [Unconjugated] - AF6020 from Novus Biologicals Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Sheep Clonality Polyclonal

SH2D2A Antibody - H00009047-B01P from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Polyclonal

SH2D2A Antibody - H00009047-D01P from Novus Biologicals Prices $399.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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