SH2D2A

Gene Symbol	SH2D2A
Entrez Gene	9047
Alt Symbol	F2771, SCAP, TSAD, VRAP
Species	Human
Gene Type	protein-coding
Description	SH2 domain containing 2A
Other Description	SH2 domain protein 2A|SH2 domain-containing protein 2A|T cell specific adapter protein TSAd|T lymphocyte specific adaptor protein|VEGF receptor-associated protein
Swissprots	Q5UBZ1 O43817 Q5VZS4 Q9NP31 Q5VZS5 Q9UPA7
Accessions	AAF69027 EAW52905 EAW52906 EAW52907 Q9NP31 AF051325 AAC99298 AF097744 AAF43260 AJ000553 CAA04185 AK222737 BAD96457 AK313706 BAG36451 AY763098 AAV34673 AY763099 AAV34674 AY763100 AAV34675 BC012107 AAH12107 BQ012931 DB128222 EU832614 ACE87705 EU832686 ACE87018 XM_006711615 XP_006711678 XM_011510113 XP_011508415 XM_011510114 XP_011508416 XM_011510115 XP_011508417 NM_001161441 NP_001154913 NM_001161442 NP_001154914 NM_001161443 NP_001154915 NM_001161444 NP_001154916 NM_003975 NP_003966
Function	Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56- LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation.
Subcellular Location	Cytoplasm.
Tissue Specificity	Expression limited to tissues of the immune system and, in particular, activated T-cells. Expressed in peripheral blood leukocytes, thymus and spleen. Much lower expression or undetectable, in brain, placenta, skeletal muscle, prostate, testis, ovary, small intestine, and colon. Expressed at low levels in unstimulated T-cells, but not expressed in normal resting or activated B-cells. According to PubMed:10692392, expression is not restricted to activated T-cells, but strongly expressed in blood cell lineages, the endothelium and other cell and tissue types, such as heart, lung, and liver.
Top Pathways	VEGF signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SH2D2A full length protein - ab160308 from Abcam Category Protein Source Wheat germ Species Human

Human SH2D2A protein fragment - ab160309 from Abcam Category Protein Source Wheat germ Species Human

SH2D2A Antibody Blocking Peptide - LS-E7815 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SH2D2A Partial Recombinant Protein - H00009047-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 2 µg Species Human

SH2D2A Recombinant Protein - H00009047-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SH2D2A-Antibody-Center-Blocking-peptide - BP5330c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SH2D2A - H00009047-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SH2D2A - H00009047-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SH2D2A - H00009047-Q01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

SH2D2A - H00009047-Q01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Source in vitro transl. Species Human

SH2D2A - H00009047-Q01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Source in vitro transl. Species Human

SH2D2A fusion protein - ag13388 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

SH2D2A fusion protein - Ag13355 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Lad (I249) Peptide - BS9161P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human SH2 domain-containing protein 2A(SH2D2A) - CSB-YP865088HU CSB-EP865088HU CSB-BP865088HU CSB-MP865088HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SH2D2A - TP304162 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

SH2D2A Blocking Peptide - abx061113 from Abbexa Category Peptide Species Human

SH2D2A Peptide, Human - M34GP14158H from Creative Peptides Category Peptide Source Synthetic. Species Human

SH2D2A Blocking Peptide - CBP5026 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

SH2 domain-containing protein 2A (SH2D2A), Recombinant Protein - MBS1342402 from MyBioSource Category Protein Prices $1,160.00, $1,160.00, $1,390.00, $1,390.00, $1,855.00, $1,855.00, $2,320.00, $2,320.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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