SH2D2A

Gene Symbol	SH2D2A
Entrez Gene	9047
Alt Symbol	F2771, SCAP, TSAD, VRAP
Species	Human
Gene Type	protein-coding
Description	SH2 domain containing 2A
Other Description	SH2 domain protein 2A|SH2 domain-containing protein 2A|T cell specific adapter protein TSAd|T lymphocyte specific adaptor protein|VEGF receptor-associated protein
Swissprots	Q5UBZ1 O43817 Q5VZS4 Q9NP31 Q5VZS5 Q9UPA7
Accessions	AAF69027 EAW52905 EAW52906 EAW52907 Q9NP31 AF051325 AAC99298 AF097744 AAF43260 AJ000553 CAA04185 AK222737 BAD96457 AK313706 BAG36451 AY763098 AAV34673 AY763099 AAV34674 AY763100 AAV34675 BC012107 AAH12107 BQ012931 DB128222 EU832614 ACE87705 EU832686 ACE87018 XM_006711615 XP_006711678 XM_011510113 XP_011508415 XM_011510114 XP_011508416 XM_011510115 XP_011508417 NM_001161441 NP_001154913 NM_001161442 NP_001154914 NM_001161443 NP_001154915 NM_001161444 NP_001154916 NM_003975 NP_003966
Function	Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56- LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation.
Subcellular Location	Cytoplasm.
Tissue Specificity	Expression limited to tissues of the immune system and, in particular, activated T-cells. Expressed in peripheral blood leukocytes, thymus and spleen. Much lower expression or undetectable, in brain, placenta, skeletal muscle, prostate, testis, ovary, small intestine, and colon. Expressed at low levels in unstimulated T-cells, but not expressed in normal resting or activated B-cells. According to PubMed:10692392, expression is not restricted to activated T-cells, but strongly expressed in blood cell lineages, the endothelium and other cell and tissue types, such as heart, lung, and liver.
Top Pathways	VEGF signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SH2D2A-Over-expression-Lysate - LY13775a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

SH2D2A 293T Cell Transient Overexpression Lysate(Denatured) - H00009047-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

SH2D2A 293T Cell Transient Overexpression Lysate(Denatured) - H00009047-T02 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

SH2D2A overexpression lysate - LY418322 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

SH2D2A overexpression lysate - LY431326 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

SH2D2A overexpression lysate - LY431896 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

SH2D2A 293 Cell Lysate - 408543 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

SH2D2A Overexpression Lysate (Denatured) - H00009047-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl Species Human

SH2D2A Overexpression Lysate (Denatured) - H00009047-T01 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl Species Human

SH2D2A Overexpression Lysate (Native) - NBL1-15920 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

SH2D2A Over-expression Lysate Product - GWB-7476F3 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

SH2D2A Overexpression Lysate (Native) - NBP2-10194 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

SH2D2A Overexpression Lysate (Denatured) - H00009047-T03 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human SH2D2A Knockdown Stable Cell Line - CSC-DC014158 from Creative biogene Category Cell Line Species Human

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