| Gene Symbol | SH2D2A |
|---|---|
| Entrez Gene | 9047 |
| Alt Symbol | F2771, SCAP, TSAD, VRAP |
| Species | Human |
| Gene Type | protein-coding |
| Description | SH2 domain containing 2A |
| Other Description | SH2 domain protein 2A|SH2 domain-containing protein 2A|T cell specific adapter protein TSAd|T lymphocyte specific adaptor protein|VEGF receptor-associated protein |
| Swissprots | Q5UBZ1 O43817 Q5VZS4 Q9NP31 Q5VZS5 Q9UPA7 |
| Accessions | AAF69027 EAW52905 EAW52906 EAW52907 Q9NP31 AF051325 AAC99298 AF097744 AAF43260 AJ000553 CAA04185 AK222737 BAD96457 AK313706 BAG36451 AY763098 AAV34673 AY763099 AAV34674 AY763100 AAV34675 BC012107 AAH12107 BQ012931 DB128222 EU832614 ACE87705 EU832686 ACE87018 XM_006711615 XP_006711678 XM_011510113 XP_011508415 XM_011510114 XP_011508416 XM_011510115 XP_011508417 NM_001161441 NP_001154913 NM_001161442 NP_001154914 NM_001161443 NP_001154915 NM_001161444 NP_001154916 NM_003975 NP_003966 |
| Function | Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56- LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation. |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | Expression limited to tissues of the immune system and, in particular, activated T-cells. Expressed in peripheral blood leukocytes, thymus and spleen. Much lower expression or undetectable, in brain, placenta, skeletal muscle, prostate, testis, ovary, small intestine, and colon. Expressed at low levels in unstimulated T-cells, but not expressed in normal resting or activated B-cells. According to PubMed:10692392, expression is not restricted to activated T-cells, but strongly expressed in blood cell lineages, the endothelium and other cell and tissue types, such as heart, lung, and liver. |
| Top Pathways | VEGF signaling pathway |
Lad CRISPR/Cas9 KO Plasmid (h) - sc-411238 from Santa Cruz Biotechnology
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Lad HDR Plasmid (h) - sc-411238-HDR from Santa Cruz Biotechnology
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Lad Double Nickase Plasmid (h) - sc-411238-NIC from Santa Cruz Biotechnology
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Lad Double Nickase Plasmid (h2) - sc-411238-NIC-2 from Santa Cruz Biotechnology
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Lad CRISPR Activation Plasmid (h) - sc-411238-ACT from Santa Cruz Biotechnology
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Lad CRISPR Activation Plasmid (h2) - sc-411238-ACT-2 from Santa Cruz Biotechnology
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Lad Lentiviral Activation Particles (h) - sc-411238-LAC from Santa Cruz Biotechnology
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Lad Lentiviral Activation Particles (h2) - sc-411238-LAC-2 from Santa Cruz Biotechnology
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Lad siRNA (h) - sc-105604 from Santa Cruz Biotechnology
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Lad shRNA Plasmid (h) - sc-105604-SH from Santa Cruz Biotechnology
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Lad shRNA (h) Lentiviral Particles - sc-105604-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU154501 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19249 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19249 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02714 from Sigma-Aldrich
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SH2D2A siRNA (Human) - CRH5968 from Cohesion Biosciences
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SH2D2A - MBS8236409 from MyBioSource
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shRNA set against Human SH2D2A (NM_003975.3) - SHH406524 from Creative biogene
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SH2D2A shRNA Plasmid (Human) - CHH5968 from Cohesion Biosciences
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SH2D2A miRNA 3'UTR clone - MiUTR3H-06874 from Creative biogene
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SH2D2A miRNA 3'UTR clone - MiUTR3H-06875 from Creative biogene
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SH2D2A miRNA 3'UTR clone - MiUTR3H-06876 from Creative biogene
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SH2D2A miRNA 3'UTR clone - MiUTR3H-06877 from Creative biogene
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SH2D2A miRNA 3'UTR clone - MiUTR3H-06878 from Creative biogene
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