| Gene Symbol |
HIRA
|
| Entrez Gene |
7290
|
| Alt Symbol |
DGCR1, TUP1, TUPLE1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
histone cell cycle regulator
|
| Other Description |
DiGeorge critical region gene 1|HIR histone cell cycle regulation defective homolog A|TUP1-like enhancer of split protein 1|protein HIRA
|
| Swissprots |
Q05BU9 Q8IXN2 P54198
|
| Accessions |
CAA62800 EAX03043 EAX03044 P54198 AK289809 BAF82498 AK299950 BAG61778 AK302835 BAH13816 AK308642 BC032721 AAH32721 BC039835 AAH39835 CR456503 CAG30389 CU013101 CAK54532 CU013389 CAK54831 X75296 CAA53044 X77633 CAA54721 X81844 CAA57436 X89887 CAA61979 NM_003325 NP_003316
|
| Function |
Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269|PubMed:12370293, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527}.
|
| Subcellular Location |
Nucleus. Nucleus, PML body. Note=Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence.
|
| Tissue Specificity |
Expressed at high levels in kidney, pancreas and skeletal muscle and at lower levels in brain, heart, liver, lung, and placenta. {ECO:0000269|PubMed:9063745}.
|