HIRA

Gene Symbol HIRA
Entrez Gene 7290
Alt Symbol DGCR1, TUP1, TUPLE1
Species Human
Gene Type protein-coding
Description histone cell cycle regulator
Other Description DiGeorge critical region gene 1|HIR histone cell cycle regulation defective homolog A|TUP1-like enhancer of split protein 1|protein HIRA
Swissprots Q05BU9 Q8IXN2 P54198
Accessions CAA62800 EAX03043 EAX03044 P54198 AK289809 BAF82498 AK299950 BAG61778 AK302835 BAH13816 AK308642 BC032721 AAH32721 BC039835 AAH39835 CR456503 CAG30389 CU013101 CAK54532 CU013389 CAK54831 X75296 CAA53044 X77633 CAA54721 X81844 CAA57436 X89887 CAA61979 NM_003325 NP_003316
Function Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269|PubMed:12370293, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527}.
Subcellular Location Nucleus. Nucleus, PML body. Note=Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence.
Tissue Specificity Expressed at high levels in kidney, pancreas and skeletal muscle and at lower levels in brain, heart, liver, lung, and placenta. {ECO:0000269|PubMed:9063745}.

HIRA CRISPR/Cas9 KO Plasmid (h) - sc-404262 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HIRA HDR Plasmid (h) - sc-404262-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HIRA Double Nickase Plasmid (h) - sc-404262-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HIRA Double Nickase Plasmid (h2) - sc-404262-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HIRA CRISPR Activation Plasmid (h) - sc-404262-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HIRA CRISPR Activation Plasmid (h2) - sc-404262-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HIRA Lentiviral Activation Particles (h) - sc-404262-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HIRA Lentiviral Activation Particles (h2) - sc-404262-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HIRA siRNA (h) - sc-43836 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HIRA shRNA Plasmid (h) - sc-43836-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HIRA shRNA (h) Lentiviral Particles - sc-43836-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HIRA RNAi - H00007290-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU061801 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10048 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10048 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06023 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr06023

HIRA siRNA (Human) - CRH4984 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HIRA - MBS8231029 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human HIRA (NM_003325.3) - SHH312329 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human HIRA(NM_003325.3) - SHH121331 from Creative biogene

Category siRNA
Species Reactivities Human

Human HIRA siRNA - orb265486 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HIRA shRNA Plasmid (Human) - CHH4984 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

HIRA miRNA 3'UTR clone - MiUTR1H-04511 from Creative biogene

Species Reactivities Human
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