| Gene Symbol |
PREX2
|
| Entrez Gene |
80243
|
| Alt Symbol |
6230420N16Rik, DEP.2, DEPDC2, P-REX2, PPP1R129
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
|
| Other Description |
DEP domain-containing protein 2|PtdIns(3,4,5)-dependent Rac exchanger 2|phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein|protein phosphatase 1, regulatory subunit 129
|
| Swissprots |
Q6R7Q3 B4DFX0 Q70Z35 Q32KL0 Q9H805 Q9H961 Q6R7Q4 Q32KL1
|
| Accessions |
Q70Z35 AJ437636 CAD26885 AK023049 BAB14375 AK024079 AK294299 BAG57581 AY508996 AAS82571 AY508997 AAS82572 AY570973 AAS59407 BC146369 AAI46370 BC148795 AAI48796 BK005160 DAA05333 BK005161 DAA05334 XM_011517612 XP_011515914 NM_024870 NP_079146 NM_025170 NP_079446
|
| Function |
Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein- coupled receptors and phosphoinositide 3-kinase. {ECO:0000269|PubMed:15304342, ECO:0000269|PubMed:15304343, ECO:0000269|PubMed:15897194}.
|
| Tissue Specificity |
Isoform 1 is highly expressed in skeletal muscle, heart and placenta, absent from peripheral blood leukocytes. Isoform 2 is expressed in skeletal muscle, kidney, small intestine, and placenta. Isoform 3 is expressed in the heart. {ECO:0000269|PubMed:15304343}.
|