PREX2

Gene Symbol PREX2
Entrez Gene 80243
Alt Symbol 6230420N16Rik, DEP.2, DEPDC2, P-REX2, PPP1R129
Species Human
Gene Type protein-coding
Description phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Other Description DEP domain-containing protein 2|PtdIns(3,4,5)-dependent Rac exchanger 2|phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein|protein phosphatase 1, regulatory subunit 129
Swissprots Q6R7Q3 B4DFX0 Q70Z35 Q32KL0 Q9H805 Q9H961 Q6R7Q4 Q32KL1
Accessions Q70Z35 AJ437636 CAD26885 AK023049 BAB14375 AK024079 AK294299 BAG57581 AY508996 AAS82571 AY508997 AAS82572 AY570973 AAS59407 BC146369 AAI46370 BC148795 AAI48796 BK005160 DAA05333 BK005161 DAA05334 XM_011517612 XP_011515914 NM_024870 NP_079146 NM_025170 NP_079446
Function Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein- coupled receptors and phosphoinositide 3-kinase. {ECO:0000269|PubMed:15304342, ECO:0000269|PubMed:15304343, ECO:0000269|PubMed:15897194}.
Tissue Specificity Isoform 1 is highly expressed in skeletal muscle, heart and placenta, absent from peripheral blood leukocytes. Isoform 2 is expressed in skeletal muscle, kidney, small intestine, and placenta. Isoform 3 is expressed in the heart. {ECO:0000269|PubMed:15304343}.

P-Rex2 (E-15) - sc-86773 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
P-Rex2 (E-15): sc-86773. Western blot analysis of P-Rex2 expression in mouse pancreas tissue extract (A) and NIH/3T3 whole cell lysate (B).

P-Rex2 (S-13) - sc-86775 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-PREX2 antibody - ab121462 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescent staining of Human cell line U-2 OS shows positivity in nuclei but not nucleoli. Recommended concentration of ab121462 1-4 µg/ml. Cells treated with PFA/Triton X-100.

Anti-PREX2 antibody - ab169027 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-PREX2 antibody (ab169027) at 1 µg/mlLane 1 : PREX2 transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.

Anti-PREX2 antibody - N-terminal - ab182482 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-PREX2 antibody - N-terminal (ab182482) at 1 µg/ml + HeLa whole cell lysate at 10 µg

Anti-DEPDC2 Antibody - LS-C307216 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-DEPDC2 Antibody (aa35-84) - LS-C201898 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human HeLa. PREX2 antibody dilution 1.0 ug/ml.

PREX2 Antibody - NBP1-84275 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PREX2 Antibody - H00080243-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-PREX2 antibody produced in rabbit - HPA015234 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-DEPDC2: <B>Cat. No. HPA015234</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human stomach shows strong cytoplasmic positivity in glandular cells.

PREX2 Antibody - N-terminal region (ARP71437_P050) - ARP71437_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PREX2 / DEPDC2 antibody - H00080243-B01P from Acris Antibodies

Prices $360.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot analysis of PREX2 expression in transfected 293T cell line (H00080243-T01) by PREX2 MaxPab polyclonal antibody. Lane 1: DEPDC2 transfected lysate(107.69 KDa). Lane 2: Non-transfected lysate.

PREX2, Polyclonal Antibody - MBS540890 from MyBioSource

Prices $390.00
Sizes 0.1 mg affinity-purified
Host Rabbit
Clonality Polyclonal

Anti-PREX2 (full length) polyclonal antibody - DPABH-07632 from Creative Diagnostics

Host Mouse
Clonality Polyclonal

Anti-PREX2 (aa 35-84) polyclonal antibody - DPABH-14028 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-PREX2 (aa 686-835) polyclonal antibody - DPABH-17987 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

PREX2, Polyclonal Antibody - MBS648052 from MyBioSource

Prices $580.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

PREX2 Antibody - PREX2-201AP from FabGennix

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DEPDC2 antibody produced in mouse - SAB1409833 from Sigma-Aldrich

Prices $357.50
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-DEPDC2: <B>Cat. No. SAB1409833</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~107.7 kDa using PREX2 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

PREX2 / DEPDC2 antibody - TA331729 from Acris Antibodies

Prices $325.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Host: Rabbit; Target Name: PREX2; Sample Tissue: Hela Whole Cell lysates; Antibody Dilution: 1.0ug/ml

PREX2 antibody - orb312592 from Biorbyt

Prices $255.00, $340.00
Sizes 100 μg, 200 μg
Host Rabbit
Clonality Polyclonal

PREX2 Antibody - CSB-PA741122LA01HU from Cusabio

Host Rabbit
Clonality Polyclonal
Western Blot<br /> Positive WB detected in:Mouse brain tissue<br /> All lanes: PREX2 antibody at 3.4ug/ml<br /> Secondary<br /> Goat polyclonal to rabbit IgG at 1/50000 dilution<br /> Predicted band size: 183,172,113 kDa<br /> Observed band size: 183,113 kDa<br />

PREX2 Antibody,Biotin conjugated - CSB-PA741122LD01HU from Cusabio

Host Rabbit
Clonality Polyclonal

PREX2 Antibody,FITC conjugated - CSB-PA741122LC01HU from Cusabio

Host Rabbit
Clonality Polyclonal

PREX2 Antibody,HRP conjugated - CSB-PA741122LB01HU from Cusabio

Host Rabbit
Clonality Polyclonal
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