| Gene Symbol | PREX2 |
|---|---|
| Entrez Gene | 80243 |
| Alt Symbol | 6230420N16Rik, DEP.2, DEPDC2, P-REX2, PPP1R129 |
| Species | Human |
| Gene Type | protein-coding |
| Description | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 |
| Other Description | DEP domain-containing protein 2|PtdIns(3,4,5)-dependent Rac exchanger 2|phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein|protein phosphatase 1, regulatory subunit 129 |
| Swissprots | Q6R7Q3 B4DFX0 Q70Z35 Q32KL0 Q9H805 Q9H961 Q6R7Q4 Q32KL1 |
| Accessions | Q70Z35 AJ437636 CAD26885 AK023049 BAB14375 AK024079 AK294299 BAG57581 AY508996 AAS82571 AY508997 AAS82572 AY570973 AAS59407 BC146369 AAI46370 BC148795 AAI48796 BK005160 DAA05333 BK005161 DAA05334 XM_011517612 XP_011515914 NM_024870 NP_079146 NM_025170 NP_079446 |
| Function | Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein- coupled receptors and phosphoinositide 3-kinase. {ECO:0000269|PubMed:15304342, ECO:0000269|PubMed:15304343, ECO:0000269|PubMed:15897194}. |
| Tissue Specificity | Isoform 1 is highly expressed in skeletal muscle, heart and placenta, absent from peripheral blood leukocytes. Isoform 2 is expressed in skeletal muscle, kidney, small intestine, and placenta. Isoform 3 is expressed in the heart. {ECO:0000269|PubMed:15304343}. |
P-Rex2 CRISPR/Cas9 KO Plasmid (h) - sc-413370 from Santa Cruz Biotechnology
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P-Rex2 HDR Plasmid (h) - sc-413370-HDR from Santa Cruz Biotechnology
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P-Rex2 Double Nickase Plasmid (h) - sc-413370-NIC from Santa Cruz Biotechnology
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P-Rex2 Double Nickase Plasmid (h2) - sc-413370-NIC-2 from Santa Cruz Biotechnology
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P-Rex2 CRISPR Activation Plasmid (h) - sc-413370-ACT from Santa Cruz Biotechnology
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P-Rex2 CRISPR Activation Plasmid (h2) - sc-413370-ACT-2 from Santa Cruz Biotechnology
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P-Rex2 Lentiviral Activation Particles (h) - sc-413370-LAC from Santa Cruz Biotechnology
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P-Rex2 Lentiviral Activation Particles (h2) - sc-413370-LAC-2 from Santa Cruz Biotechnology
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P-Rex2 siRNA (h) - sc-77461 from Santa Cruz Biotechnology
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P-Rex2 shRNA Plasmid (h) - sc-77461-SH from Santa Cruz Biotechnology
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P-Rex2 shRNA (h) Lentiviral Particles - sc-77461-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU060301 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17393 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17393 from Sigma-Aldrich
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PREX2 siRNA (Human) - CRJ2823 from Cohesion Biosciences
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shRNA set against Human PREX2 (NM_025170.4) - SHH382456 from Creative biogene
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shRNA set against Human DEPDC2(NM_025170.4) - SHR138616 from Creative biogene
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shRNA set against Human DEPDC2(NM_024870.2) - SHR138892 from Creative biogene
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Human PREX2 siRNA - orb273324 from Biorbyt
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PREX2 shRNA Plasmid (Human) - CHJ2823 from Cohesion Biosciences
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PREX2 miRNA 3'UTR clone - MiUTR1H-02778 from Creative biogene
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PREX2 miRNA 3'UTR clone - MiUTR1H-02779 from Creative biogene
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