| Gene Symbol | HIST2H2AB |
|---|---|
| Entrez Gene | 317772 |
| Alt Symbol | H2AB |
| Species | Human |
| Gene Type | protein-coding |
| Description | histone cluster 2, H2ab |
| Other Description | histone 2, H2ab|histone H2A type 2-B |
| Swissprots | Q8IUE6 |
| Accessions | AAN59958 CAI12570 EAW53603 Q8IUE6 BC172330 AAI72330 NM_175065 NP_778235 |
| Function | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Subcellular Location | Nucleus. Chromosome. |
| Top Pathways | Systemic lupus erythematosus, Alcoholism |
Mouse HIST2H2AB ORF clone (NM_175065.2) - CDCL117355 from Creative biogene
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Human HIST2H2AB cDNA Clone(NM_175065.2) - CDFG011152 from Creative biogene
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