Gene Symbol | HIST2H2AB |
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Entrez Gene | 317772 |
Alt Symbol | H2AB |
Species | Human |
Gene Type | protein-coding |
Description | histone cluster 2, H2ab |
Other Description | histone 2, H2ab|histone H2A type 2-B |
Swissprots | Q8IUE6 |
Accessions | AAN59958 CAI12570 EAW53603 Q8IUE6 BC172330 AAI72330 NM_175065 NP_778235 |
Function | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
Subcellular Location | Nucleus. Chromosome. |
Top Pathways | Systemic lupus erythematosus, Alcoholism |
Histone cluster 2 H2AB CRISPR/Cas9 KO Plasmid (h) - sc-415471 from Santa Cruz Biotechnology
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Histone cluster 2 H2AB HDR Plasmid (h) - sc-415471-HDR from Santa Cruz Biotechnology
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Histone cluster 2 H2AB Double Nickase Plasmid (h) - sc-415471-NIC from Santa Cruz Biotechnology
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Histone cluster 2 H2AB Double Nickase Plasmid (h2) - sc-415471-NIC-2 from Santa Cruz Biotechnology
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Histone cluster 2 H2AB CRISPR Activation Plasmid (h) - sc-415471-ACT from Santa Cruz Biotechnology
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Histone cluster 2 H2AB CRISPR Activation Plasmid (h2) - sc-415471-ACT-2 from Santa Cruz Biotechnology
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Histone cluster 2 H2AB Lentiviral Activation Particles (h) - sc-415471-LAC from Santa Cruz Biotechnology
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Histone cluster 2 H2AB Lentiviral Activation Particles (h2) - sc-415471-LAC-2 from Santa Cruz Biotechnology
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Histone cluster 2 H2AB siRNA (h) - sc-105508 from Santa Cruz Biotechnology
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Histone cluster 2 H2AB shRNA Plasmid (h) - sc-105508-SH from Santa Cruz Biotechnology
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Histone cluster 2 H2AB shRNA (h) Lentiviral Particles - sc-105508-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN10107 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10107 from Sigma-Aldrich
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HIST2H2AB siRNA (Human) - CRJ7195 from Cohesion Biosciences
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Histone H2ab RNAi - H00317772-R01 from Novus Biologicals
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HIST2H2AB - MBS8204192 from MyBioSource
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shRNA set against Human HIST2H2AB (NM_175065.2) - SHH312885 from Creative biogene
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shRNA set against Human HIST2H2AB(NM_175065.2) - SHH123545 from Creative biogene
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HIST2H2AB shRNA Plasmid (Human) - CHJ7195 from Cohesion Biosciences
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HIST2H2AB miRNA 3'UTR clone - MiUTR1H-04565 from Creative biogene
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