Gene Symbol | DOK7 |
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Entrez Gene | 285489 |
Alt Symbol | C4orf25, CMS1B |
Species | Human |
Gene Type | protein-coding |
Description | docking protein 7 |
Other Description | downstream of tyrosine kinase 7|protein Dok-7 |
Swissprots | Q86XG5 Q8NBC1 Q6P6A6 A2A499 A2RRD4 Q18PE1 Q8N2J3 E9PB56 |
Accessions | EAW82463 Q18PE1 AB220918 BAE96739 AK075037 BAC11367 AK091037 BAC03572 AK096456 BAC04795 BC043568 AAH43568 BC062369 AAH62369 BC131544 AAI31545 BC141852 AAI41853 BM684814 DA205628 DA823926 XM_011513435 XP_011511737 XM_011513436 XP_011511738 XM_011513437 XP_011511739 NM_001164673 NP_001158145 NM_001256896 NP_001243825 NM_001301071 NP_001288000 NM_173660 NP_775931 |
Function | Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK. {ECO:0000269|PubMed:20603078}. |
Subcellular Location | Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Accumulates at neuromuscular junctions. {ECO:0000250}. |
Tissue Specificity | Preferentially expressed in skeletal muscle and heart. Present in thigh muscle, diaphragm and heart but not in the liver or spleen (at protein level). {ECO:0000269|PubMed:16794080}. |
Human DOK7 peptide - ab90998 from Abcam
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DOK7 Antibody Blocking Peptide - LS-E2532 from LifeSpan Bioscience
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DOK7 Antibody Blocking Peptide - LS-E22563 from LifeSpan Bioscience
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DOK7-Antibody-N-term-Blocking-peptide - BP13568a from Abgent, a WuXi AppTec company
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DOK7 Blocking Peptide - 33R-7809 from Fitzgerald
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DOK7 fusion protein - ag18543 from Proteintech Group
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DOK7 fusion protein - ag18627 from Proteintech Group
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Recombinant Docking Protein 7 (DOK7) - RPF377Ra01 from Uscn Life Science Inc.
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Recombinant Human Protein Dok-7(DOK7) - CSB-YP623281HU CSB-EP623281HU CSB-BP623281HU CSB-MP623281HU from Cusabio
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DOK7 - TP319267 from Acris Antibodies
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DOK7 Recombinant Protein Antigen - NBP2-32465PEP from Novus Biologicals
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DOK7 Blocking Peptide - abx061226 from Abbexa
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DOK7 Peptide, Human - M34GP04489H from Creative Peptides
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DOK7 Blocking Peptide - CBP5139 from Cohesion Biosciences
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DOK7 peptide - orb319285 from Biorbyt
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Protein Dok-7 (DOK7), Recombinant Protein - MBS1311800 from MyBioSource
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