DOK7

Gene Symbol DOK7
Entrez Gene 285489
Alt Symbol C4orf25, CMS1B
Species Human
Gene Type protein-coding
Description docking protein 7
Other Description downstream of tyrosine kinase 7|protein Dok-7
Swissprots Q86XG5 Q8NBC1 Q6P6A6 A2A499 A2RRD4 Q18PE1 Q8N2J3 E9PB56
Accessions EAW82463 Q18PE1 AB220918 BAE96739 AK075037 BAC11367 AK091037 BAC03572 AK096456 BAC04795 BC043568 AAH43568 BC062369 AAH62369 BC131544 AAI31545 BC141852 AAI41853 BM684814 DA205628 DA823926 XM_011513435 XP_011511737 XM_011513436 XP_011511738 XM_011513437 XP_011511739 NM_001164673 NP_001158145 NM_001256896 NP_001243825 NM_001301071 NP_001288000 NM_173660 NP_775931
Function Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK. {ECO:0000269|PubMed:20603078}.
Subcellular Location Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Accumulates at neuromuscular junctions. {ECO:0000250}.
Tissue Specificity Preferentially expressed in skeletal muscle and heart. Present in thigh muscle, diaphragm and heart but not in the liver or spleen (at protein level). {ECO:0000269|PubMed:16794080}.

Dok-7 CRISPR/Cas9 KO Plasmid (h) - sc-404184 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dok-7 HDR Plasmid (h) - sc-404184-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dok-7 Double Nickase Plasmid (h) - sc-404184-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dok-7 Double Nickase Plasmid (h2) - sc-404184-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dok-7 CRISPR Activation Plasmid (h) - sc-404184-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dok-7 CRISPR Activation Plasmid (h2) - sc-404184-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dok-7 Lentiviral Activation Particles (h) - sc-404184-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dok-7 Lentiviral Activation Particles (h2) - sc-404184-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dok-7 siRNA (h) - sc-61852 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Dok-7 shRNA Plasmid (h) - sc-61852-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Dok-7 shRNA (h) Lentiviral Particles - sc-61852-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN7433 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7433 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07688 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr07688

DOK7 siRNA (Human) - CRJ7100 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DOK7 - MBS8203020 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human DOK7 (NM_173660.4) - SHH280333 from Creative biogene

Category siRNA
Species Reactivities Human

DOK7 shRNA Plasmid (Human) - CHJ7100 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

DOK7 miRNA 3'UTR clone - MiUTR4H-TG02835 from Creative biogene

Species Reactivities Human
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